Protection of mice from lethal infection with Aujeszky's disease virus by immunization with purified gVI.

The Journal of general virology ·Vol. 69 ( Pt 6) ·1988-06-00 ·Pages 1411-4

Ishii H, Kobayashi Y, Kuroki M, Kodama Y

Abstract

Virus envelope glycoprotein gVI (gp50) of Aujeszky's disease virus (ADV) was purified from a Nonidet P40-solubilized lysate of ADV-infected Vero cells by immunoaffinity chromatography using a monoclonal antibody against gVI. Mice immunized by the purified gVI produced virus-neutralizing antibody and were successfully protected against subsequent challenge with ADV.

MeSH Terms

Animals Antibodies, Viral/biosynthesis Chromatography, Affinity Herpesvirus 1, Suid/immunology Immunization Immunoassay Mice Mice, Inbred BALB C Pseudorabies/prevention & control Vero Cells Viral Envelope Proteins/immunology,isolation & purification Viral Vaccines

Chemicals

Antibodies, Viral Viral Envelope Proteins Viral Vaccines pseudorabies virus glycoproteins

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Ishii H

Ghen Corporation, Gifu Laboratory, Japan.

Kobayashi Y

Kuroki M

Kodama Y

Article Info

Journal

The Journal of general virology

Abbr.

J Gen Virol

ISSN

0022-1317

DOI

10.1099/0022-1317-69-6-1411

Published

1988-06-00

Pages

1411-4

Language

English

Region

England

NLM ID

0077340

Subset

External Links

PubMed source DOI: 10.1099/0022-1317-69-6-1411 View journal details

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Protection of mice from lethal infection with Aujeszky's disease virus by immunization with purified gVI.

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