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PMID: 2839774 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Transcriptional autoregulation of the proto-oncogene fos.

Nature ·Vol. 334 ·No. 6180 ·1988-07-28 ·Pages 314-9

Sassone-Corsi P, Sisson JC, Verma IM

Abstract

Serum-induced transcription of the proto-oncogene fos is under negative feedback regulation mediated by the fos protein. The fos promoter region responsive to repression is also required for serum inducibility and binds a nucleoprotein complex in which the nuclear factor AP-1 is associated with fos protein.

MeSH Terms
Animals Base Sequence Blood DNA Restriction Enzymes/metabolism Heat-Shock Proteins/genetics Humans Mice Molecular Sequence Data Promoter Regions, Genetic Proto-Oncogene Mas Proto-Oncogenes Transcription, Genetic
Chemicals
Heat-Shock Proteins MAS1 protein, human Proto-Oncogene Mas DNA Restriction Enzymes
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Sassone-Corsi P
Molecular Biology and Virology Laboratory, Salk Institute, San Diego, California 92138.
Sisson J C
Verma I M
Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
DOI
10.1038/334314a0
Published
1988-07-28
Pages
314-9
Language
English
Region
England
NLM ID
0410462
Subset
IM
External Links
PubMed source DOI: 10.1038/334314a0 View journal details
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