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PMID: 2845275 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

The HIV tat gene induces dermal lesions resembling Kaposi's sarcoma in transgenic mice.

Nature ·Vol. 335 ·No. 6191 ·1988-10-13 ·Pages 606-11

Vogel J, Hinrichs SH, Reynolds RK, Luciw PA, Jay G

Abstract

When the human immunodeficiency virus transactivating gene under the control of the viral regulatory region is introduced into the germline of mice, skin lesions are induced that resemble Kaposi's sarcoma seen in AIDS. Our findings indicate that HIV could play a direct part in causing cancer.

MeSH Terms

Animals Base Sequence Cell Division Gene Products, tat HIV/genetics Male Mice Mice, Transgenic Molecular Sequence Data RNA, Messenger/metabolism Sarcoma, Kaposi/genetics,pathology Skin/metabolism,pathology Skin Neoplasms/genetics,pathology Transcription Factors/metabolism tat Gene Products, Human Immunodeficiency Virus

Chemicals

Gene Products, tat RNA, Messenger Transcription Factors tat Gene Products, Human Immunodeficiency Virus

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Vogel J

Laboratory of Molecular Virology, National Cancer Institute, Bethesda, Maryland 20892.

Hinrichs S H

Reynolds R K

Luciw P A

Jay G

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/335606a0

Published

1988-10-13

Pages

606-11

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/335606a0 View journal details

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The HIV tat gene induces dermal lesions resembling Kaposi's sarcoma in transgenic mice.

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