In vitro activities of T-3262, NY-198, fleroxacin (AM-833; RO 23-6240), and other new quinolone agents against clinically isolated Chlamydia trachomatis strains.

Antimicrobial agents and chemotherapy ·Vol. 32 ·No. 7 ·1988-07-00 ·Pages 1080-1

Maeda H, Fujii A, Nakata K, Arakawa S, Kamidono S

Abstract

The in vitro activities of three newly developed quinolone drugs (T-3262, NY-198, and fleroxacin [AM-833; RO 23-6240]) against 10 strains of clinically isolated Chlamydia trachomatis were assessed and compared with those of other quinolones and minocycline. T-3262 (MIC for 90% of isolates tested, 0.1 microgram/ml) was the most active of the quinolones. The NY-198 and fleroxacin MICs for 90% of isolates were 3.13 and 62.5 micrograms/ml, respectively.

MeSH Terms

Anti-Infective Agents/pharmacology Chlamydia/drug effects Ciprofloxacin/analogs & derivatives,pharmacology Fleroxacin Fluoroquinolones Naphthyridines Quinolones/pharmacology

Chemicals

Anti-Infective Agents Fluoroquinolones Naphthyridines Quinolones Ciprofloxacin tosufloxacin lomefloxacin Fleroxacin

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Maeda H

Department of Urology, School of Medicine, Kobe University, Japan.

Fujii A

Nakata K

Arakawa S

Kamidono S

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18 references, click to expand

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Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.32.7.1080

Published

1988-07-00

Pages

1080-1

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC172348

Subset

External Links

PubMed source DOI: 10.1128/AAC.32.7.1080 PMC Full Text View journal details

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In vitro activities of T-3262, NY-198, fleroxacin (AM-833; RO 23-6240), and other new quinolone agents against clinically isolated Chlamydia trachomatis strains.

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