The kinetics of expression of individual herpes simplex virus type 1 transcripts.
We have used specific single-stranded DNA probes cloned in M13 to analyze the kinetics of expression of 20 individual herpes simplex virus type 1 (HSV-1) transcripts, most of known function. The three alpha transcripts studied all differ in the details of their shut-off. There are at least three groups of beta or early transcripts which differ both in the time of their maximum rate of synthesis and in the time of their shut off. Similarly late (beta gamma and gamma) transcripts form a complex group all of which share the fact that their rates of synthesis reach a maximum at a time when beta transcripts are being shut off.
16 references, click to expand
-
A membrane-filter technique for the detection of complementary DNA.Biochem Biophys Res Commun. 1966 Jun 13;23(5):641-6 PMID: 5963888
-
Mutations in the major DNA-binding protein gene of herpes simplex virus type 1 result in increased levels of viral gene expression.J Virol. 1983 Sep;47(3):478-86 PMID: 6312079
-
Regulation of herpesvirus macromolecular synthesis. VIII. The transcription program consists of three phases during which both extent of transcription and accumulation of RNA in the cytoplasm are regulated.J Virol. 1979 Aug;31(2):299-314 PMID: 225555
-
Repression of adenovirus early gene expression by coinfection with a temperature-sensitive mutant in the immediate-early gene of pseudorabies virus.J Virol. 1986 Jan;57(1):13-7 PMID: 3001339
-
Herpes simplex virus type 1 ICP27 is an essential regulatory protein.J Virol. 1985 Sep;55(3):796-805 PMID: 2991596
-
Genetic analysis of temperature-sensitive mutants which define the gene for the major herpes simplex virus type 1 DNA-binding protein.J Virol. 1983 Jan;45(1):354-66 PMID: 6296442
-
A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments.Gene. 1982 Oct;19(3):269-76 PMID: 6295880
-
Regulation of herpesvirus macromolecular synthesis: sequential transition of polypeptide synthesis requires functional viral polypeptides.Proc Natl Acad Sci U S A. 1975 Apr;72(4):1276-80 PMID: 165503
-
Nonstructural proteins of herpes simplex virus. II. Major virus-specific DNa-binding protein.J Virol. 1981 Sep;39(3):894-902 PMID: 6270358
-
Molecular genetics of herpes simplex virus. VII. Characterization of a temperature-sensitive mutant produced by in vitro mutagenesis and defective in DNA synthesis and accumulation of gamma polypeptides.J Virol. 1981 Jan;37(1):191-206 PMID: 6260973
-
Transcriptional control of herpesvirus gene expression: gene functions required for positive and negative regulation.Proc Natl Acad Sci U S A. 1986 Jan;83(2):256-60 PMID: 3001729
-
Herpes simplex virus mRNA species mapping in EcoRI fragment I.J Virol. 1982 Aug;43(2):594-607 PMID: 6287033
-
Regulation of herpesvirus macromolecular synthesis. I. Cascade regulation of the synthesis of three groups of viral proteins.J Virol. 1974 Jul;14(1):8-19 PMID: 4365321
-
Herpes simplex virus type 1 HindIII fragment L encodes spliced and complementary mRNA species.J Virol. 1981 Aug;39(2):559-72 PMID: 6268843
-
Characterization of the genes encoding herpes simplex virus type 1 and type 2 alkaline exonucleases and overlapping proteins.J Virol. 1986 Mar;57(3):1023-36 PMID: 3005609
-
Viral DNA synthesis is required for the efficient expression of specific herpes simplex virus type 1 mRNA species.Virology. 1980 Feb;101(1):10-24 PMID: 6243816
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