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PMID: 2860945 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Relation between consumption of alcohol and fatty acids esterifying serum cholesterol in healthy men.

British medical journal (Clinical research ed.) ·Vol. 290 ·No. 6485 ·1985-06-22 ·Pages 1859-61

Warnet JM, Cambien F, Vernier V, Pecoraro M, Flament C, Ducimetiere P, Jacqueson A, Richard JL, Claude JR

Abstract

The relation between consumption of alcohol (established by interview), two of its typical markers (gamma-glutamyltransferase activity and mean corpuscular volume), and the composition of fatty acids in plasma cholesterol esters was investigated in an epidemiological study of 1467 actively employed men aged 35-45. In this group of subjects mean consumption of alcohol was 34.6 (SD 25.2) g/day. Palmitoleic acid and oleic acid were positively correlated with consumption of alcohol, gamma-glutamyltransferase activity, and mean corpuscular volume, while linoleic acid was negatively correlated with these variables. When these three fatty acids, gamma-glutamyltransferase activity, mean corpuscular volume, and the fat content of the diet were introduced into a multivariate regression analysis, with consumption of alcohol as the dependent variable, only palmitoleic acid, gamma-glutamyltransferase activity, mean corpuscular volume, and the monounsaturated fat content of the diet remained significant. Palmitoleic acid seems to be an independent correlate of consumption of alcohol and could be useful in epidemiological and clinical studies as a variable of consumption.

MeSH Terms
Adult Alcohol Drinking Cholesterol Esters/blood Dietary Fats/analysis Erythrocyte Indices Fatty Acids/analysis Fatty Acids, Monounsaturated Humans Male Middle Aged Palmitic Acids/analysis gamma-Glutamyltransferase/blood
Chemicals
Cholesterol Esters Dietary Fats Fatty Acids Fatty Acids, Monounsaturated Palmitic Acids palmitoleic acid gamma-Glutamyltransferase
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Warnet J M
Cambien F
Vernier V
Pecoraro M
Flament C
Ducimetiere P
Jacqueson A
Richard J L
Claude J R
References (20)
20 references, click to expand
  1. Effect of ethanol administration on fatty acid desaturation.
    Lipids. 1980 Apr;15(4):263-8 PMID: 7374380
  2. Essential fatty acids in chronic alcoholism.
    Acta Med Scand Suppl. 1979;631:1-38 PMID: 291299
  3. Fatty acid composition of serum and adipose tissue lipids in males with chronic renal failure. Relations to serum lipoproteins and clinical factors.
    Acta Med Scand. 1982;211(1-2):75-85 PMID: 7072524
  4. Direct determination of the linoleate/oleate ratio in serum cholesterol esters by liquid chromatography.
    Clin Chem. 1982 Apr;28(4 Pt 1):676-80 PMID: 7074839
  5. Low dietary intake of linoleic acid predisposes to myocardial infarction.
    Br Med J (Clin Res Ed). 1982 Sep 11;285(6343):683-4 PMID: 6809186
  6. Alcohol and coronary heart disease in Puerto Rico.
    Am J Epidemiol. 1983 May;117(5):538-50 PMID: 6846312
  7. Ethanol ingestion and polyunsaturated fatty acids: effects on the acyl-CoA desaturases.
    Alcohol Clin Exp Res. 1983 Spring;7(2):220-6 PMID: 6408939
  8. A simple method for the isolation and purification of total lipides from animal tissues.
    J Biol Chem. 1957 May;226(1):497-509 PMID: 13428781
  9. PATHOGENESIS OF ETHANOL-INDUCED FATTY LIVER. 3. IN VIVO AND VITRO EFFECTS OF ETHANOL ON HEPATIC FATTY ACID METABOLISM IN RATS.
    J Lipid Res. 1965 Apr;6:269-77 PMID: 14330769
  10. Role of dietary, adipose, and endogenously synthesized fatty acids in the pathogenesis of the alcoholic fatty liver.
    J Clin Invest. 1966 Jan;45(1):51-62 PMID: 5901179
  11. Effects of prolonged ethanol intake in man: role of dietary adipose, and endogenously synthesized fatty acids in the pathogenesis of the alcoholic fatty liver.
    J Clin Invest. 1966 Sep;45(9):1400-11 PMID: 4162127
  12. Hepatic fatty acids after ethanol ingestion.
    Nutr Dieta Eur Rev Nutr Diet. 1968;10(3):224-8 PMID: 5695816
  13. A new method for the determination of gamma-glutamyltransferase in serum.
    J Clin Chem Clin Biochem. 1976 Sep;14(9):421-7 PMID: 9466
  14. Coffee, alcohol and risk of coronary heart disease among Japanese men living in Hawaii.
    N Engl J Med. 1977 Aug 25;297(8):405-9 PMID: 882109
  15. Fatty acids and ischaemic heart-disease.
    Lancet. 1978 May 27;1(8074):1146-7 PMID: 77429
  16. [Statistical discrimination between alcoholics and non-alcoholics by use of fatty infiltration, fatty-acid pattern and enzyme-activities of the human liver (author's transl)].
    Z Rechtsmed. 1978 Nov 10;82(2):113-20 PMID: 735444
  17. Effects of ethanol on lipid metabolism.
    J Lipid Res. 1979 Mar;20(3):289-315 PMID: 87483
  18. Gas-chromatographic analysis of patterns of fatty acids of cholesteryl esters and phosphatidylcholine.
    Clin Chem. 1979 Aug;25(8):1411-4 PMID: 455678
  19. Methanolysis of cholesteryl esters: conditions for quantitative preparation of methyl esters.
    Anal Biochem. 1979 Apr 15;94(2):402-8 PMID: 464311
  20. Alcohol consumption in a healthy population. Relationship to gamma-glutamyl transferase activity and mean corpuscular volume.
    JAMA. 1981 May 1;245(17):1748-51 PMID: 6111616
Article Info
Journal
British medical journal (Clinical research ed.)
Abbr.
Br Med J (Clin Res Ed)
ISSN
0267-0623
DOI
10.1136/bmj.290.6485.1859
Published
1985-06-22
Pages
1859-61
Language
English
Region
England
NLM ID
8302911
PMCID
PMC1416826
Subset
IM
External Links
PubMed source DOI: 10.1136/bmj.290.6485.1859 PMC Full Text
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