Home LiteratureArticle Details
PMID: 287015 Published · ppublish English Journal Article

Prostaglandin D2 formation by malignant melanoma cells correlates inversely with cellular metastatic potential.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 76 ·No. 4 ·1979-04-00 ·Pages 1765-9

Fitzpatrick FA, Stringfellow DA

Abstract

B16 malignant melanoma cell lines transform arachidonic acid and its transient metabolite, prostaglandin endoperoxide H2, into prostaglandin D2. The highly metastatic line, B16 F10, forms less prostaglandin D2 compared to the moderately metastatic parent line, B16 F1. Since platelet aggregation may be one factor involved in B16 metastasis and since prostaglandin D2 inhibits platelet aggregation, this prostaglandin could affect the outcome of platelet-tumour interactions, which may contribute ultimately to metastasis. Arachidonic acid metabolism may be another one of the intrinsic biochemical properties of tumor cells that affects their metastasis. Our results suggest that quantitative release of unusual prostaglandins must be considered in this context.

MeSH Terms
Arachidonic Acids/metabolism Cell Line Chromatography, Gas Melanoma/metabolism Neoplasm Metastasis Prostaglandins/biosynthesis Prostaglandins D/biosynthesis Prostaglandins H/metabolism
Chemicals
Arachidonic Acids Prostaglandins Prostaglandins D Prostaglandins H
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Fitzpatrick F A
Stringfellow D A
References (30)
30 references, click to expand
  1. Prostaglandin levels in normal and transformed baby-hamster-kidney fibroblasts.
    Nat New Biol. 1973 May 9;243(123):50-1 PMID: 17315365
  2. Conversions of prostaglandin endoperoxides by glutathione-S-transferases and serum albumins.
    Biochim Biophys Acta. 1976 Dec 20;450(3):450-61 PMID: 1009099
  3. Elevation of adenosine 3',5'-monophosphate levels in 3T3 fibroblasts by arachidonic acid: evidence for mediation by prostaglandin I2.
    FEBS Lett. 1977 Sep 15;81(2):415-8 PMID: 200482
  4. Prostaglandin production by normal and transformed 3T3 fibroblasts in cell culture.
    Eur J Biochem. 1977 Mar 15;74(1):7-12 PMID: 192548
  5. The role of lipids in platelet function: with particular reference to the arachidonic acid pathway.
    J Lipid Res. 1978 Sep;19(7):793-826 PMID: 101634
  6. Prostacyclin is the major prostaglandin released from the isolated perfused rabbit and rat heart.
    Nature. 1977 Jul 14;268(5616):160-3 PMID: 339097
  7. Pharmacological modification of thromboxane and prostaglandin release in cardiac anaphylaxis.
    Prostaglandins. 1978 May;15(5):889-900 PMID: 704912
  8. Identification of prostaglandin D2 as a major prostaglandin in homogenates of rat brain.
    Prostaglandins. 1977 Oct;14(4):633-43 PMID: 594367
  9. Prostaglandins H1 and H2. Convenient biochemical synthesis and isolation. Further biological and spectroscopic characterization.
    Prostaglandins. 1977 Jun;13(6):1043-53 PMID: 887795
  10. Oximes for high performance liquid and electron capture gas chromatography of prostaglandins and thromboxanes.
    Anal Chem. 1977 Jun;49(7):1032-5 PMID: 860828
  11. Biosynthesis of prostaglandin D2. 1. Formation of prostaglandin D2 by human platelets.
    Prostaglandins. 1977 Feb;13(2):225-34 PMID: 847230
  12. Characterization in vivo and in vitro of tumor cells selected for resistance to syngeneic lymphocyte-mediated cytotoxicity.
    Cancer Res. 1976 Sep;36(9 pt.1):3160-5 PMID: 975082
  13. Prostaglandin D2 inhibits the aggregation of human platelets.
    Thromb Res. 1974 Sep;5(3):291-9 PMID: 4439372
  14. Production of prostaglandins by cells in vitro: radioimmunoassay measurement of the conversion of arachidonic acid to PGE2 and PGF2 alpha.
    Biochem Biophys Res Commun. 1973 Dec 10;55(3):724-9 PMID: 4761081
  15. Biochemical parameters correlated with tumour cell implantation.
    Nature. 1973 Dec 21-28;246(5434):487-9 PMID: 4762197
  16. Platelet-tumor-cell interactions in mice. The role of platelets in the spread of malignant disease.
    Int J Cancer. 1973 May;11(3):704-18 PMID: 4801854
  17. Selection of successive tumour lines for metastasis.
    Nat New Biol. 1973 Apr 4;242(118):148-9 PMID: 4512654
  18. Prostaglandin d2 as a potential antithrombotic agent.
    Prostaglandins. 1975 Jan;9(1):109-21 PMID: 806102
  19. Environment of the blood-borne tumor embolus adherent to vessel wall.
    J Med. 1973;4(3):150-77 PMID: 4589261
  20. Detection and isolation of an endoperoxide intermediate in prostaglandin biosynthesis.
    Proc Natl Acad Sci U S A. 1973 Mar;70(3):899-903 PMID: 4514999
  21. Inhibition of pulmonary metastasis by intravenous injection of specifically activated macrophages.
    Cancer Res. 1974 May;34(5):1074-8 PMID: 4842910
  22. Microangiopathic haemolytic anaemia and experimental tumour-cell emboli.
    Br J Haematol. 1974 Apr;26(4):651-9 PMID: 4845651
  23. Immune stimulation-inhibition of experimental cancer metastasis.
    Cancer Res. 1974 Mar;34(3):491-8 PMID: 4812256
  24. Isolation and properties of intermediates in prostaglandin biosynthesis.
    Biochim Biophys Acta. 1973 Dec 20;326(3):448-61 PMID: 4776443
  25. The adhesion of thromboplastic tumour emboli to vessel walls in vivo.
    Br J Exp Pathol. 1972 Jun;53(3):301-13 PMID: 5055714
  26. Inhibition of arachidonic acid release from cells as the biochemical action of anti-inflammatory corticosteroids.
    Proc Natl Acad Sci U S A. 1976 May;73(5):1730-4 PMID: 1064044
  27. Isomerization of prostaglandin H2 into prostaglandin D2 in the presence of serum albumin.
    Biochim Biophys Acta. 1976 Apr 22;431(1):189-83 PMID: 1268242
  28. Stimulation of prostaglandin biosynthesis by vasoactive substances in methylcholanthrene-transformed mouse BALB/3T3.
    J Biol Chem. 1976 Feb 10;251(3):776-80 PMID: 942951
  29. Organ specificity of blood-borne tumour metastasis determined by cell adhesion?
    Nature. 1975 May 15;255(5505):230-2 PMID: 1143319
  30. Biological behavior of malignant melanoma cells correlated to their survival in vivo.
    Cancer Res. 1975 Jan;35(1):218-24 PMID: 1109790
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.76.4.1765
Published
1979-04-00
Pages
1765-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC383471
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.76.4.1765 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2