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PMID: 2871621 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Pathogenesis of disease caused by Entamoeba histolytica: studies of adherence, secreted toxins, and contact-dependent cytolysis.

Reviews of infectious diseases ·Vol. 8 ·No. 2 ·1986-00-00 ·Pages 247-60

Ravdin JI

Abstract

Amebiasis is due to invasion of the colonic mucosa by the enteric protozoan Entamoeba histolytica. The biology of the parasite and the pathogenic mechanisms of E. histolytica have been extensively studied. Recent studies provide new insights into the mechanism by which amebas colonize the gut, interact with bacterial flora, adhere to and lyse tissue, and combat the host's inflammatory response. Elucidation of the biochemical and cellular bases of the pathogenesis of disease caused by E. histolytica may lead to the development of an immunologic or pharmacologic means of prophylaxis.

MeSH Terms
Acetylgalactosamine/pharmacology Acetylglucosaminidase/analysis Adhesiveness Age Factors Animals Bacterial Physiological Phenomena Calcium/physiology Cricetinae Cricetulus Cytotoxins/analysis,toxicity Entamoeba histolytica/analysis,pathogenicity,ultrastructure Entamoebiasis/etiology Galactose/pharmacology Glutaral Humans Hydrogen-Ion Concentration Immunity, Cellular Intestinal Mucosa/parasitology Lectins/analysis Molecular Weight Nutritional Physiological Phenomena Virulence
Chemicals
Cytotoxins Lectins Acetylglucosaminidase Acetylgalactosamine Calcium Glutaral Galactose
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Ravdin J I
Article Info
Journal
Reviews of infectious diseases
Abbr.
Rev Infect Dis
ISSN
0162-0886
DOI
10.1093/clinids/8.2.247
Published
1986-00-00
Pages
247-60
Language
English
Region
United States
NLM ID
7905878
Subset
IM
Grants
NIAID NIH HHS · R01AI18843TMP · United States
External Links
PubMed source DOI: 10.1093/clinids/8.2.247
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