CPP, a new potent and selective NMDA antagonist. Depression of central neuron responses, affinity for [3H]D-AP5 binding sites on brain membranes and anticonvulsant activity.

2-Amino-5-phosphonovalerate Animals Anticonvulsants Aspartic Acid/analogs & derivatives,antagonists & inhibitors Binding Sites Brain/drug effects,metabolism,physiology Cats Cell Membrane/metabolism Interneurons/physiology Membrane Potentials/drug effects Mice Motor Neurons/physiology N-Methylaspartate Neurons/drug effects,physiology Piperazines/pharmacology Rats Spinal Cord/drug effects,physiology Valine/analogs & derivatives,metabolism

Anticonvulsants Piperazines Aspartic Acid N-Methylaspartate 2-Amino-5-phosphonovalerate 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid Valine