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PMID: 2877813 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

A polymorphic human myosin heavy chain locus is linked to an anonymous single copy locus (D17S1) at 17p13.

Cytogenetics and cell genetics ·Vol. 43 ·No. 1-2 ·1986-00-00 ·Pages 117-20

Schwartz CE, McNally E, Leinwand L, Skolnick MH

Abstract

Restriction fragment length polymorphisms (RFLPs) have been developed for an adult human skeletal muscle myosin heavy chain gene which was previously mapped to the short arm of human chromosome 17. Using RFLP analysis of DNA from 140 individuals, we have found tight linkage (LOD score of 6.9) between this myosin heavy chain gene and the anonymous DNA probe, D17S1.

MeSH Terms

Adult Chromosomes, Human, Pair 17 DNA/isolation & purification Female Genes Genetic Linkage Humans Male Myosin Subfragments Myosins/genetics Pedigree Peptide Fragments/genetics Polymorphism, Genetic Polymorphism, Restriction Fragment Length

Chemicals

Myosin Subfragments Peptide Fragments DNA Myosins

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Schwartz C E

McNally E

Leinwand L

Skolnick M H

Article Info

Journal

Cytogenetics and cell genetics

Abbr.

Cytogenet Cell Genet

ISSN

0301-0171

DOI

10.1159/000132307

Published

1986-00-00

Pages

117-20

Language

English

Region

Switzerland

NLM ID

0367735

Subset

Grants

NCI NIH HHS · CA28854 · United States

NIGMS NIH HHS · GM29090 · United States

NIGMS NIH HHS · GM36295 · United States

External Links

PubMed source DOI: 10.1159/000132307

Analysis Services

A polymorphic human myosin heavy chain locus is linked to an anonymous single copy locus (D17S1) at 17p13.

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