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PMID: 2877873 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Sequential expression of murine homeo box genes during F9 EC cell differentiation.

The EMBO journal ·Vol. 5 ·No. 9 ·1986-09-00 ·Pages 2209-15

Breier G, Bućan M, Francke U, Colberg-Poley AM, Gruss P

Abstract

We have isolated and characterized a previously unknown member of the murine homeo box family. The new locus, m31, is located on chromosome 15 and is more homologous to sequences contained in the Drosophila homeotic gene, Antp, than to any other known murine homeo box. We show that this gene encodes a 2.7 kb mRNA which is expressed during mouse embryogenesis and during differentiation of F9 teratocarcinoma cells into parietal endoderm cells. The transcript appears late in this differentiation process and is most abundant at a time when the F9 cells begin to express tissue-specific markers and the expression of another murine homeo box gene, m6, has decreased.

MeSH Terms
Animals Cell Line Chromosome Mapping DNA Restriction Enzymes Drosophila/genetics Embryo, Mammalian Embryo, Nonmammalian Genes, Homeobox Humans Mice Nucleic Acid Hybridization RNA, Messenger/genetics Sequence Homology, Nucleic Acid Species Specificity Transcription, Genetic Xenopus
Chemicals
RNA, Messenger DNA Restriction Enzymes
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Breier G
Bućan M
Francke U
Colberg-Poley A M
Gruss P
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1986-09-00
Pages
2209-15
Language
English
Region
England
NLM ID
8208664
PMCID
PMC1167102
Subset
IM
Grants
NIGMS NIH HHS · GM 26105 · United States
External Links
PubMed source PMC Full Text View journal details
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