Home LiteratureArticle Details

PMID: 2880163 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Association between tumour necrosis factor in serum and fatal outcome in patients with meningococcal disease.

Lancet (London, England) ·Vol. 1 ·No. 8529 ·1987-02-14 ·Pages 355-7

Waage A, Halstensen A, Espevik T

Abstract

Serum samples taken on admission from 79 patients with meningococcal meningitis, septicaemia, or both, were examined in a highly sensitive bioassay for tumour necrosis factor (TNF). TNF was detected in samples from 10 of 11 patients who died but from only 8 of 68 survivors. All 5 patients with serum TNF levels over 440 units/ml (corresponding to 0.1 ng/ml recombinant TNF) died.

MeSH Terms

Adolescent Adult Aged Aged, 80 and over Child Child, Preschool Female Glycoproteins/blood Humans Infant Male Meningitis, Meningococcal/blood,mortality Meningococcal Infections/blood,mortality Middle Aged Tumor Necrosis Factor-alpha

Chemicals

Glycoproteins Tumor Necrosis Factor-alpha

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Waage A

Halstensen A

Espevik T

Article Info

Journal

Lancet (London, England)

Abbr.

Lancet

ISSN

0140-6736

DOI

10.1016/s0140-6736(87)91728-4

Published

1987-02-14

Pages

355-7

Language

English

Region

England

NLM ID

2985213R

Subset

External Links

PubMed source DOI: 10.1016/s0140-6736(87)91728-4 View journal details

Analysis Services

Association between tumour necrosis factor in serum and fatal outcome in patients with meningococcal disease.

Contact

WeChat Official Account