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PMID: 2880213 Published · ppublish English Clinical Trial Comparative Study Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't

Immunotherapy versus chemotherapy in localised cutaneous leishmaniasis.

Lancet (London, England) ·Vol. 1 ·No. 8530 ·1987-02-21 ·Pages 401-5

Convit J, Castellanos PL, Rondon A, Pinardi ME, Ulrich M, Castes M, Bloom B, Garcia L

Abstract

In a randomised trial a combination vaccine consisting of live BCG together with killed leishmania promastigotes was compared with a standard antimonial regimen in 94 patients with localised cutaneous leishmaniasis. Three vaccinations over 32 weeks gave a similar cure rate (94%) to three 20-day courses of meglumine antimonate. In the immunotherapy group side-effects were few (5.8%) and slight whereas in the chemotherapy group they were frequent (52.4%) and often serious. Immunotherapy is a low-cost, low-risk alternative to chemotherapy in localised cutaneous leishmaniasis, applicable by primary health services in rural areas.

MeSH Terms
Adolescent Adult Antibodies/analysis Antigens, Protozoan/administration & dosage Antiprotozoal Agents/adverse effects,therapeutic use Child Clinical Trials as Topic Female Humans Immunotherapy/methods Leishmania mexicana/immunology Leishmaniasis/immunology,therapy Male Meglumine/adverse effects,therapeutic use Meglumine Antimoniate Middle Aged Mycobacterium bovis/immunology Organometallic Compounds/adverse effects,therapeutic use Random Allocation Skin Tests Sorbitol/analogs & derivatives Vaccination
Chemicals
Antibodies Antigens, Protozoan Antiprotozoal Agents Organometallic Compounds Sorbitol Meglumine Meglumine Antimoniate
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Convit J
Castellanos P L
Rondon A
Pinardi M E
Ulrich M
Castes M
Bloom B
Garcia L
Article Info
Journal
Lancet (London, England)
Abbr.
Lancet
ISSN
0140-6736
DOI
10.1016/s0140-6736(87)90116-4
Published
1987-02-21
Pages
401-5
Language
English
Region
England
NLM ID
2985213R
Subset
IM
External Links
PubMed source DOI: 10.1016/s0140-6736(87)90116-4 View journal details
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