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PMID: 2883890 Published · ppublish English Journal Article

Linkage disequilibrium of plasminogen polymorphisms and assignment of the gene to human chromosome 6q26-6q27.

American journal of human genetics ·Vol. 40 ·No. 4 ·1987-04-00 ·Pages 338-50

Murray JC, Buetow KH, Donovan M, Hornung S, Motulsky AG, Disteche C, Dyer K, Swisshelm K, Anderson J, Giblett E

Abstract

Linkage disequilibrium was observed between newly identified DNA polymorphisms and a previously described protein polymorphism for plasminogen. This finding implies that the two types of polymorphisms describe variation at the same locus. The plasminogen gene was mapped to chromosomal bands 6q26-q27 using somatic-cell hybrids and in situ hybridization. Linkage disequilibrium between protein and DNA polymorphisms has utility in substituting for protein typing in instances where only DNA samples are available, such as from deceased individuals or extinct species. The technique may be useful when cross-hybridizing sequences make the interpretation of Southern blot patterns difficult and may obviate the need for extensive DNA sequencing. In some cases, disequilibrium may provide information useful for determining the appropriate direction for chromosome walks from a marker locus to a target locus.

MeSH Terms
Alleles Animals Chromosomes, Human, Pair 6/ultrastructure Genetic Linkage Humans Hybrid Cells/analysis Mice Plasminogen/genetics Polymorphism, Restriction Fragment Length
Chemicals
Plasminogen
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Murray J C
Buetow K H
Donovan M
Hornung S
Motulsky A G
Disteche C
Dyer K
Swisshelm K
Anderson J
Giblett E
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Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
Published
1987-04-00
Pages
338-50
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1684087
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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