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PMID: 29029603 Published · epublish English Journal Article Review Research Support, Non-U.S. Gov't

The pathophysiological role of mitochondrial oxidative stress in lung diseases.

Journal of translational medicine ·Vol. 15 ·No. 1 ·2017-00-13 ·Pages 207

Liu X, Chen Z

Abstract

Mitochondria are critically involved in reactive oxygen species (ROS)-dependent lung diseases, such as lung fibrosis, asbestos, chronic airway diseases and lung cancer. Mitochondrial DNA (mtDNA) encodes mitochondrial proteins and is more sensitive to oxidants than nuclear DNA. Damage to mtDNA causes mitochondrial dysfunction, including electron transport chain impairment and mitochondrial membrane potential loss. Furthermore, damaged mtDNA also acts as a damage-associated molecular pattern (DAMP) that drives inflammatory and immune responses. In this review, crosstalk among alveolar epithelial cells, alveolar macrophages and mitochondria is examined. ROS-related transcription factors and downstream cell signaling pathways are also discussed. We conclude that targeting oxidative stress with antioxidant agents, such as thiol molecules, polyphenols and superoxide dismutase (SOD), and promoting mitochondrial biogenesis should be considered as novel strategies for treating lung diseases that currently have no effective treatment options.

Keywords
Antioxidant agents Mitochondrial DNA Reactive oxygen species
MeSH Terms
Animals DNA Damage DNA, Mitochondrial/genetics Humans Lung Diseases/pathology,physiopathology Mitochondria/metabolism Oxidative Stress Reactive Oxygen Species/metabolism
Chemicals
DNA, Mitochondrial Reactive Oxygen Species
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Liu Xiaojing
Respiratory Division of Zhongshan Hospital, Shanghai Institute of Respiratory Diseases, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, China. | Geriatric Department, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No 600 Yishan Road, Shanghai, China.
Chen Zhihong
Respiratory Division of Zhongshan Hospital, Shanghai Institute of Respiratory Diseases, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, China. [email protected].
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Article Info
Journal
Journal of translational medicine
Abbr.
J Transl Med
ISSN
1479-5876
DOI
10.1186/s12967-017-1306-5
Email
[email protected]
Published
2017-00-13
Epub
2017-00-13
Pages
207
Language
English
Region
England
NLM ID
101190741
PMCID
PMC5640915
Subset
IM
External Links
PubMed source DOI: 10.1186/s12967-017-1306-5 PMC Full Text View journal details
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