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PMID: 2904653 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

A cloned octamer transcription factor stimulates transcription from lymphoid-specific promoters in non-B cells.

Nature ·Vol. 336 ·No. 6199 ·1988-12-08 ·Pages 544-51

Müller MM, Ruppert S, Schaffner W, Matthias P

Abstract

The complementary DNA coding for a lymphocyte-specific transcription factor binding to the DNA 'octamer' sequence TNATTTGCAT has been cloned. The nucleotide sequence shows homology to the homoeobox domain. Expression of this cDNA in HeLa cells is sufficient for a strong transcriptional activation of B-cell-specific promoters.

MeSH Terms

Amino Acid Sequence B-Lymphocytes/metabolism Base Sequence Cell Line Cloning, Molecular Genes Genes, Homeobox Humans Lymphocytes/metabolism Molecular Sequence Data Promoter Regions, Genetic Transcription Factors/genetics,physiology

Chemicals

Transcription Factors

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Müller M M

Institut für Molekularbiologie II der Universität Zürich, Switzerland.

Ruppert S

Schaffner W

Matthias P

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/336544a0

Published

1988-12-08

Pages

544-51

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/336544a0 View journal details

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A cloned octamer transcription factor stimulates transcription from lymphoid-specific promoters in non-B cells.

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