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PMID: 2904654 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

A human lymphoid-specific transcription factor that activates immunoglobulin genes is a homoeobox protein.

Nature ·Vol. 336 ·No. 6199 ·1988-12-08 ·Pages 551-7

Scheidereit C, Cromlish JA, Gerster T, Kawakami K, Balmaceda CG, Currie RA, Roeder RG

Abstract

The human lymphoid-specific transcription factor OTF-2 contains a homoeodomain that is required for DNA binding and binds specifically to DNA elements that are recognized by Drosophila homoeodomain proteins, suggesting coevolutionary relationships between mammalian and invertebrate homoeodomain proteins and their DNA recognition elements.

MeSH Terms

Amino Acid Sequence Base Sequence Cloning, Molecular DNA-Binding Proteins Gene Expression Regulation Genes, Homeobox Genes, Immunoglobulin Humans Lymphocytes/immunology Molecular Sequence Data Octamer Transcription Factor-2 Protein Conformation RNA, Messenger/genetics Sequence Homology, Nucleic Acid Species Specificity Transcription Factors/genetics,immunology Transcription, Genetic

Chemicals

DNA-Binding Proteins Octamer Transcription Factor-2 POU2F2 protein, human RNA, Messenger Transcription Factors

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Scheidereit C

Laboratory of Biochemistry and Molecular Biology, Rockefeller University, New York, New York 10021.

Cromlish J A

Gerster T

Kawakami K

Balmaceda C G

Currie R A

Roeder R G

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/336551a0

Published

1988-12-08

Pages

551-7

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/336551a0 View journal details

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A human lymphoid-specific transcription factor that activates immunoglobulin genes is a homoeobox protein.

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