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PMID: 2911348 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The bicoid protein is a positive regulator of hunchback transcription in the early Drosophila embryo.

Nature ·Vol. 337 ·No. 6203 ·1989-01-12 ·Pages 138-43

Driever W, Nüsslein-Volhard C

Abstract

A gradient in concentration of the protein product of the bicoid gene is a determinant of the anterior-posterior axis of Drosophila embryos. By binding upstream of the segmentation gene hunchback the bicoid protein controls its transcription, thereby translating maternal pattern-generating information into differential activation of zygotic gene expression.

MeSH Terms

Animals Base Sequence Drosophila/embryology,genetics Drosophila Proteins Embryo, Nonmammalian/physiology Genes Genes, Regulator Homeodomain Proteins Insect Hormones/genetics,physiology Molecular Sequence Data Restriction Mapping Trans-Activators Transcription, Genetic

Chemicals

Drosophila Proteins Homeodomain Proteins Insect Hormones Trans-Activators bcd protein, Drosophila

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Driever W

Max Planck Institut für Entwicklungsbiologie, Abteilung III Genetik, Tübingen, FRG.

Nüsslein-Volhard C

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/337138a0

Published

1989-01-12

Pages

138-43

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/337138a0 View journal details

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The bicoid protein is a positive regulator of hunchback transcription in the early Drosophila embryo.

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