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PMID: 291943 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Mathematical model for studying genetic variation in terms of restriction endonucleases.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 76 ·No. 10 ·1979-10-00 ·Pages 5269-73

Nei M, Li WH

Abstract

A mathematical model for the evolutionary change of restriction sites in mitochondrial DNA is developed. Formulas based on this model are presented for estimating the number of nucleotide substitutions between two populations or species. To express the degree of polymorphism in a population at the nucleotide level, a measure called "nucleotide diversity" is proposed.

MeSH Terms
Base Sequence Computers DNA Restriction Enzymes DNA, Mitochondrial Genetic Variation Mathematics Models, Biological
Chemicals
DNA, Mitochondrial DNA Restriction Enzymes
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Nei M
Li W H
References (11)
11 references, click to expand
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    Proc Natl Acad Sci U S A. 1979 Apr;76(4):1967-71 PMID: 109836
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    Genetics. 1979 May;92(1):279-95 PMID: 499767
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    Nucleic Acids Res. 1977;4(5):1257-65 PMID: 896461
  5. Mapping of mitochondrial DNA of individual sheep and goats: rapid evolution in the D loop region.
    Cell. 1977 Jul;11(3):571-83 PMID: 884736
  6. Distribution of nucleotide differences between two randomly chosen cistrons in a finite population.
    Genetics. 1977 Feb;85(2):331-7 PMID: 863231
  7. Evolution of mitochondrial DNA sequences in Xenopus.
    Dev Biol. 1972 Oct;29(2):139-51 PMID: 5075787
  8. Specific cleavage analysis of mammalian mitochondrial DNA.
    Proc Natl Acad Sci U S A. 1975 Nov;72(11):4496-500 PMID: 1060130
  9. On the number of segregating sites in genetical models without recombination.
    Theor Popul Biol. 1975 Apr;7(2):256-76 PMID: 1145509
  10. Fitting discrete probability distributions to evolutionary events.
    Science. 1971 Jun 11;172(3988):1089-96 PMID: 5574514
  11. The number of heterozygous nucleotide sites maintained in a finite population due to steady flux of mutations.
    Genetics. 1969 Apr;61(4):893-903 PMID: 5364968
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.76.10.5269
Published
1979-10-00
Pages
5269-73
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC413122
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.76.10.5269 PMC Full Text View journal details
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