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PMID: 2920020 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Identification of an androgen-repressed mRNA in rat ventral prostate as coding for sulphated glycoprotein 2 by cDNA cloning and sequence analysis.

The Biochemical journal ·Vol. 257 ·No. 1 ·1989-01-01 ·Pages 293-6

Bettuzzi S, Hiipakka RA, Gilna P, Liao ST

Abstract

The concentrations of a small number of mRNAs in the rat ventral prostate increase after castration and then decrease upon androgen treatment. Since the repression of specific gene expression may be important in the regulation of organ growth, we have cloned a cDNA for an androgen-repressed mRNA, the concentration of which increased 17-fold 4 days after castration, and this increase was reversed rapidly by androgen treatment. By sequence analysis the androgen-repressed mRNA was identified as that coding for sulphated glycoprotein 2.

MeSH Terms
Androgens/physiology Animals Base Sequence Cloning, Molecular Clusterin Gene Expression Regulation Glycoproteins/genetics Male Molecular Chaperones Orchiectomy Prostate/analysis RNA, Messenger/analysis Rats
Chemicals
Androgens Clu protein, rat Clusterin Glycoproteins Molecular Chaperones RNA, Messenger
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Bettuzzi S
Ben May Institute, University of Chicago, IL 60637.
Hiipakka R A
Gilna P
Liao S T
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24 references, click to expand
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj2570293
Published
1989-01-01
Pages
293-6
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1135572
Subset
IM
Grants
NIDDK NIH HHS · DK 09461 · United States
NIDDK NIH HHS · DK 37694 · United States
Databases
GENBANK
X13231
External Links
PubMed source DOI: 10.1042/bj2570293 PMC Full Text View journal details
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