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PMID: 2933196 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Vaccination with a purified blood-stage malaria antigen in mice: correlation of protection with T cell mediated immunity.

Clinical and experimental immunology ·Vol. 62 ·No. 1 ·1985-10-00 ·Pages 19-23

Playfair JH, De Souza JB, Freeman RR, Holder AA

Abstract

A purified 230,000 mol wt protein antigen from the lethal mouse malaria parasite Plasmodium yoelii YM which had previously been shown to be highly effective as a vaccine, was tested for its ability to stimulate specific helper T cells and T cells responsible for delayed hypersensitivity. Strong stimulation was found in both assays, but larger doses were required for delayed hypersensitivity, correlating well with the requirements for protection. It is suggested that T stimulation may be a requirement for effective protection by purified antigens in malaria.

MeSH Terms
Animals Antigens, Protozoan/immunology Female Hypersensitivity, Delayed/immunology Immunity, Cellular Malaria/immunology,prevention & control Mice Mice, Inbred BALB C Mice, Inbred C57BL Plasmodium/immunology T-Lymphocytes/immunology T-Lymphocytes, Helper-Inducer/immunology Vaccination
Chemicals
Antigens, Protozoan
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Playfair J H
De Souza J B
Freeman R R
Holder A A
References (17)
17 references, click to expand
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Article Info
Journal
Clinical and experimental immunology
Abbr.
Clin Exp Immunol
ISSN
0009-9104
Published
1985-10-00
Pages
19-23
Language
English
Region
England
NLM ID
0057202
PMCID
PMC1577400
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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