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PMID: 2937147 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Molecular genetics of human color vision: the genes encoding blue, green, and red pigments.

Science (New York, N.Y.) ·Vol. 232 ·No. 4747 ·1986-04-11 ·Pages 193-202

Nathans J, Thomas D, Hogness DS

Abstract

Human color vision is based on three light-sensitive pigments. The isolation and sequencing of genomic and complementary DNA clones that encode the apoproteins of these three pigments are described. The deduced amino acid sequences show 41 +/- 1 percent identity with rhodopsin. The red and green pigments show 96 percent mutual identity but only 43 percent identity with the blue pigment. Green pigment genes vary in number among color-normal individuals and, together with a single red pigment gene, are proposed to reside in a head-to-tail tandem array within the X chromosome.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Biological Evolution Cattle Cebidae Cercopithecidae Color Color Perception/physiology DNA/metabolism Drosophila melanogaster Eye Proteins/genetics,physiology Genes Humans Molecular Sequence Data Nucleic Acid Hybridization Photoreceptor Cells/physiology RNA, Messenger/genetics Retinal Pigments/genetics Retinaldehyde/physiology Rhodopsin/genetics Rod Opsins X Chromosome
Chemicals
Eye Proteins RNA, Messenger Retinal Pigments Rod Opsins long-wavelength opsin middle-wavelength opsin DNA Rhodopsin Retinaldehyde
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Nathans J
Thomas D
Hogness D S
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
DOI
10.1126/science.2937147
Published
1986-04-11
Pages
193-202
Language
English
Region
United States
NLM ID
0404511
Subset
IM
Databases
GENBANK
K03490, K03491, K03492, K03493, K03494, K03495, K03496, K03497, M13295, M13296, M13297, M13298, M13299, M13300, M13301, M13302, M13303, M13304, M13305, M13306
External Links
PubMed source DOI: 10.1126/science.2937147 View journal details
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