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PMID: 2941291 Published · ppublish English Clinical Trial Journal Article Randomized Controlled Trial

Treatment of uncomplicated gonococcal urethritis in men with two dosages of ciprofloxacin.

European journal of clinical microbiology ·Vol. 5 ·No. 2 ·1986-04-00 ·Pages 244-6

Tegelberg-Stassen MJ, van der Hoek JC, Mooi L, Wagenvoort JH, van Joost T, Michel MF, Stolz E

Abstract

One hundred and sixty-four male patients suffering from urethral gonorrhoea were treated in an open randomised trial with either 250 mg (n = 85) or 500 mg (n = 79) ciprofloxacin administered in one tablet. Cure rates in both groups were 100%. Postgonococcal urethritis was observed in 31 of 85 (36%) patients in the first group, and in 21 of 79 patients (27%) in the second group. Side-effects were minor, occurring in four patients in the 250 mg group (4.7%) and in seven in the 500 mg group (8.9%). The side-effects consisted of nausea, diarrhoea and headache. Ciprofloxacin would appear to be a very effective drug in the treatment of urethral gonorrhoea in males.

MeSH Terms

Administration, Oral Adolescent Adult Anti-Bacterial Agents/administration & dosage,adverse effects,pharmacology,therapeutic use Ciprofloxacin Gonorrhea/drug therapy,microbiology Humans Male Middle Aged Neisseria gonorrhoeae/drug effects Quinolines/administration & dosage,adverse effects,pharmacology,therapeutic use Random Allocation Urethra/microbiology Urethritis/drug therapy,microbiology

Chemicals

Anti-Bacterial Agents Quinolines Ciprofloxacin

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Tegelberg-Stassen M J

van der Hoek J C

Mooi L

Wagenvoort J H

van Joost T

Michel M F

Stolz E

References (9)

9 references, click to expand

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Antimicrob Agents Chemother. 1983 Nov;24(5):784-6 PMID: 6660852
In vitro activity of Bay 09867, a new quinoline derivative, compared with those of other antimicrobial agents.
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In vitro activities of the spectinomycin analog U-63366 and four quinolone derivatives against Neisseria gonorrhoeae.
Antimicrob Agents Chemother. 1984 Oct;26(4):608-9 PMID: 6240224
Penicillinase-producing gonococci in the Netherlands in 1981.
J Antimicrob Chemother. 1983 Jan;11(1):15-20 PMID: 6402480
Antibiotic sensitivities of gonococci isolated in Rotterdam and results of treatment with cefuroxime.
Br J Vener Dis. 1980 Aug;56(4):249-51 PMID: 6775767
Single dose ciprofloxacin for treating gonococcal infections in men.
Genitourin Med. 1985 Oct;61(5):302-5 PMID: 2931345
Pharmacokinetics of ciprofloxacin after oral and intravenous administration in healthy volunteers.
Eur J Clin Microbiol. 1984 Aug;3(4):355-9 PMID: 6489326
Gonorrhea in Rotterdam caused by penicillinase-producing gonococci.
Br J Vener Dis. 1980 Aug;56(4):244-8 PMID: 6775766
Treatment of non-complicated urogenital, rectal and oropharyngeal gonorrhoea with intramuscular cefotaxime 1.0 g or cefuroxime 1.5 g.
J Antimicrob Chemother. 1984 Sep;14 Suppl B:295-9 PMID: 6094455

Article Info

Journal

European journal of clinical microbiology

Abbr.

Eur J Clin Microbiol

ISSN

0722-2211

DOI

10.1007/BF02013999

Published

1986-04-00

Pages

244-6

Language

English

Region

Germany

NLM ID

8219582

Subset

External Links

PubMed source DOI: 10.1007/BF02013999

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Treatment of uncomplicated gonococcal urethritis in men with two dosages of ciprofloxacin.

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