Serum bactericidal activity of two newer quinolones against Salmonella typhi compared with standard therapeutic regimens.

European journal of clinical microbiology ·Vol. 5 ·No. 3 ·1986-06-00 ·Pages 297-302

Trautmann M, Krause B, Birnbaum D, Wagner J, Lenk V

Abstract

The bactericidal activity of two newer quinolones, ciprofloxacin and ofloxacin, against eight strains of Salmonella typhi was examined by the serum dilution test and studies of bacterial killing kinetics in human serum, and compared to standard regimens. Bactericidal titers for ciprofloxacin ranged from 1:388 to 1:119 two hours and from 1:119 to 1:57 six hours after volunteers received an oral dose of 500 mg. The respective titers obtained after a 200 mg oral dose of ofloxacin were somewhat lower, but still exceeded 1:16 in all instances. Studies of bacterial killing kinetics demonstrated a rapid bactericidal action of both drugs against all strains tested. Compared to the classical anti-typhoid agents chloramphenicol, cotrimoxazole and amoxicillin, the new quinolones showed both markedly higher bactericidal titers and more rapid killing of Salmonella typhi in human serum.

MeSH Terms

Adult Amoxicillin/blood,pharmacology Chloramphenicol/blood,pharmacology Ciprofloxacin Drug Combinations/blood,pharmacology Female Humans Kinetics Male Microbial Sensitivity Tests Middle Aged Ofloxacin Oxazines/blood,pharmacology Quinolines/blood,pharmacology Salmonella typhi/drug effects Sulfamethoxazole/blood,pharmacology Trimethoprim/blood,pharmacology Trimethoprim, Sulfamethoxazole Drug Combination

Chemicals

Drug Combinations Oxazines Quinolines Ciprofloxacin Chloramphenicol Amoxicillin Trimethoprim, Sulfamethoxazole Drug Combination Ofloxacin Trimethoprim Sulfamethoxazole

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Trautmann M

Krause B

Birnbaum D

Wagner J

Lenk V

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26 references, click to expand

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Article Info

Journal

European journal of clinical microbiology

Abbr.

Eur J Clin Microbiol

ISSN

0722-2211

DOI

10.1007/BF02017785

Published

1986-06-00

Pages

297-302

Language

English

Region

Germany

NLM ID

8219582

Subset

External Links

PubMed source DOI: 10.1007/BF02017785

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Serum bactericidal activity of two newer quinolones against Salmonella typhi compared with standard therapeutic regimens.

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