Home LiteratureArticle Details
PMID: 2944481 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Concentration of ciprofloxacin in human prostatic tissue after oral administration.

Antimicrobial agents and chemotherapy ·Vol. 30 ·No. 1 ·1986-07-00 ·Pages 88-9

Dan M, Golomb J, Gorea A, Braf Z, Berger SA

Abstract

Concomitant concentrations of ciprofloxacin in serum, urine, and prostatic tissue were determined in 15 patients after single oral doses of 750 mg. Levels in tissue ranged from 0.6 to 4.18 micrograms/g, and therapeutic concentrations were demonstrable for up to 9 h after administration. The mean ratio of tissue to serum concentration was 0.93 +/- 0.08 (standard error).

MeSH Terms
Administration, Oral Aged Ciprofloxacin Humans Kinetics Male Middle Aged Prostate/metabolism Quinolines/administration & dosage,blood,metabolism
Chemicals
Quinolines Ciprofloxacin
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Dan M
Golomb J
Gorea A
Braf Z
Berger S A
References (9)
9 references, click to expand
  1. Pharmacokinetics and tissue penetration of ciprofloxacin.
    Antimicrob Agents Chemother. 1983 Nov;24(5):784-6 PMID: 6660852
  2. Ciprofloxacin, a quinolone carboxylic acid compound active against aerobic and anaerobic bacteria.
    Antimicrob Agents Chemother. 1984 Mar;25(3):319-26 PMID: 6232895
  3. The activity of ciprofloxacin and other 4-quinolones against Chlamydia trachomatis and Mycoplasmas in vitro.
    Eur J Clin Microbiol. 1984 Aug;3(4):344-6 PMID: 6237903
  4. Diffusion of ciprofloxacin into prostatic fluid.
    Eur J Clin Microbiol. 1984 Aug;3(4):360-2 PMID: 6489327
  5. Comparison of high-pressure liquid chromatography and microbiological assay for the determination of biliary elimination of ciprofloxacin in humans.
    Antimicrob Agents Chemother. 1985 Aug;28(2):311-4 PMID: 2939796
  6. Ciprofloxacin distribution in prostatic tissue and fluid following oral administration.
    Chemotherapy. 1985;31(1):13-8 PMID: 3156024
  7. Prostatitis, prostatosis, and prostatodynia.
    Urology. 1985 May;25(5):439-59 PMID: 3887726
  8. Comparison of high-pressure liquid chromatography and bioassay for determination of ciprofloxacin in serum and urine.
    Antimicrob Agents Chemother. 1985 Mar;27(3):353-6 PMID: 3158274
  9. Intraprostatic concentration of ciprofloxacin and its activity against urinary pathogens.
    J Antimicrob Chemother. 1984 Dec;14(6):641-5 PMID: 6440885
Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.30.1.88
Published
1986-07-00
Pages
88-9
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC176441
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.30.1.88 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2