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PMID: 295401 Published · ppublish English Journal Article

Variation of gene conversion and intragenic recombination frequencies in the genome of Ascobolus immersus.

Molecular & general genetics : MGG ·Vol. 176 ·No. 1 ·1979-10-02 ·Pages 129-38

Nicolas A

Abstract

Eighty mutants in 17 ascospore character genes were studied for their conversion patterns. The correlation between conversion pattern and mutagenic origin, previously found in genes b1 and b2 was extended to all the genes studied. Aberrant 4:4 asci were found in most genes irrespective of their conversion frequency. From gene to gene, the conversion frequency showed an almost 100 times variation. The frequency of intragenic recombination also showed sharp variation from gene to gene. The mean conversion frequency and the maximal intragenic recombination frequency were shown to be highly correlated in 5 genes for which these 2 values are known. This correlation was extended to 12 other genes in other Ascomycetes: Saccharomyces cerevisiae, Schizosaccharomyces pombe, Neurospora, and Sordaria. From this study it is concluded that, 1) the probability of hybrid DNA formation undergoes considerable changes according to the region of the genome; 2) the intragenic recombination frequency primarily reflects the frequency of hybrid DNA formation rather than the physical length of the gene; 3) for a given physical distance on the DNA, a similar fraction of the gene conversion events lead to recombination in the 5 Ascomycetes.

MeSH Terms
Ascomycota/genetics Gene Conversion Genes Genetic Variation Mutation Recombination, Genetic Spores, Fungal
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Nicolas A
References (35)
35 references, click to expand
  1. Recombination events that span sites within neighbouring gene loci of Neurospora.
    Genet Res. 1970 Feb;15(1):109-21 PMID: 5415222
  2. The use of gene conversion to study synaptinemal complex structure and molecular details of chromatid pairing in meiosis.
    Mol Gen Genet. 1977 Nov 29;157(1):31-7 PMID: 340914
  3. The genetic fine structure of nonsense suppressors in Schizosaccharomyces pombe : I. sup3 and sup9.
    Curr Genet. 1979 Dec;1(1):45-61 PMID: 24190807
  4. Genetics of Sordaria fimicola. VII. Gene conversion at the G locus in interallelic crosses.
    Genetics. 1969 May;62(1):23-66 PMID: 5371017
  5. The genetics of Sordaria brevicollis. 3. Gene conversion involving a series of hyaline ascospore color mutants.
    Genetics. 1967 Oct;57(2):483-93 PMID: 5584577
  6. ABERRANT RECOMBINATION OF PYRIDOXINE MUTANTS OF Neurospora.
    Proc Natl Acad Sci U S A. 1955 Apr 15;41(4):215-20 PMID: 16589648
  7. Disparity of gene conversion in frameshift mutants located in locus b2 of Ascobolus immersus.
    Proc Natl Acad Sci U S A. 1979 Jun;76(6):2871-5 PMID: 16592666
  8. EVIDENCE FROM TETRAD ANALYSIS FOR BOTH NORMAL AND ABERRANT RECOMBINATION BETWEEN ALLELIC MUTANTS IN Neurospora Crassa.
    Proc Natl Acad Sci U S A. 1958 May;44(5):378-90 PMID: 16590210
  9. Some aspects of recombination in eukaryotic organisms.
    Annu Rev Genet. 1975;9:129-44 PMID: 1108763
  10. THE ANALYSIS OF GENETIC RECOMBINATION ON THE POLARON HYBRID DNA MODEL.
    Genet Res. 1965 Feb;6:27-92 PMID: 14297596
  11. [On the existence of a polarized genetic unit which does not undergo non-reciprocal exchanges].
    C R Hebd Seances Acad Sci. 1960 May 16;250:3408-10 PMID: 14417486
  12. X-ray and meiotic fine structure mapping of the adenine-8 locus in Saccharomyces cerevisiae.
    Genetics. 1968 Apr;58(4):507-27 PMID: 5685163
  13. Aberrant 4:4 asci, disparity in the direction of conversion, and frequencies of conversion in Ascobolus immersus.
    Cold Spring Harb Symp Quant Biol. 1979;43 Pt 2:1343-52 PMID: 290447
  14. Site Specific Induction of Gene Conversion in SCHIZOSACCHAROMYCES POMBE.
    Genetics. 1971 Nov;69(3):317-37 PMID: 17248549
  15. Mapping and gene conversion studies with the structural gene for iso-1-cytochrome C in yeast.
    Genetics. 1975 Dec;81(4):615-29 PMID: 174970
  16. Genetics of Sordaria fimicola. VI. Gene conversion at the g locus in mutant X wild type crosses.
    Genetics. 1967 Dec;57(4):767-82 PMID: 6082621
  17. Gene conversion in higher organisms: non-reciprocal recombination events at the rosy cistron in Drosophila melanogaster.
    Genet Res. 1971 Apr;17(2):139-49 PMID: 4999444
  18. Recombination mechanisms at the pan-2 locus in Neurospora crassa.
    Cold Spring Harb Symp Quant Biol. 1958;23:119-35 PMID: 13635549
  19. BIOCHEMICAL AND MORPHOLOGICAL MUTANTS OF ASCOBOLUS IMMERSUS.
    Genetics. 1964 Nov;50:987-98 PMID: 14239781
  20. Evidence for meiotic recombination in Ascobolus involving only one member of a tetrad.
    Genetics. 1971 Jul;68(3):401-13 PMID: 5127403
  21. Conversion-associated recombination in yeast (hybrids-meiosis-tetrads-marker loci-models).
    Proc Natl Acad Sci U S A. 1972 Jan;69(1):101-5 PMID: 4550500
  22. Meiotic gene conversion in yeast tetrads and the theory of recombination.
    Genetics. 1967 Oct;57(2):455-81 PMID: 5584576
  23. ALLELIC RECOMBINATION IN NEUROSPORA: TETRAD ANALYSIS OF A THREE-POINT CROSS WITHIN THE PAN-2 LOCUS.
    Genetics. 1964 Mar;49:529-40 PMID: 14135412
  24. [On the probable size of reciprocal exchanges in complex locus of Ascobolus immersus].
    C R Acad Sci Hebd Seances Acad Sci D. 1966 Mar 14;262(11):1250-3 PMID: 4956425
  25. Mechanism of gene conversion in Ascobolus immersus. 3. The interaction of heteroallelas in the conversion process.
    Mol Gen Genet. 1973 Apr 12;122(2):165-82 PMID: 4702195
  26. Meiotic gene conversion: a signal of the basic recombination event in yeast.
    Cold Spring Harb Symp Quant Biol. 1979;43 Pt 2:1325-41 PMID: 290446
  27. The mechanism of intragenic recombination.
    Annu Rev Genet. 1973;7:113-27 PMID: 4361264
  28. Is recombination confined to structural genes on the eukaryotic genome?
    Nature. 1977 Aug 4;268(5619):460-2 PMID: 895854
  29. Gene conversion in nonsense suppressors of Schizosaccharomyces pombe : II. Specific marker effects.
    Curr Genet. 1980 Feb;1(2):89-95 PMID: 24190832
  30. Recombination in yeast.
    Annu Rev Genet. 1971;5:219-36 PMID: 16097656
  31. Gene conversion and intragenic recombination at the SUP6 locus and the surrounding region in Saccharomyces cerevisiae.
    Genetics. 1976 Dec;84(4):697-721 PMID: 795715
  32. Role of DNA sequences in genetic recombination in the iso-1-cytochrome c gene of yeast. II. Comparison of mutants altered at the same and nearby base pairs.
    Genetics. 1977 Jan;85(1):1-22 PMID: 190084
  33. The suppression of gene conversion and intragenic crossing over in Ascobolus immersus: evidence for modifiers acting in the heterozygous state.
    Genetics. 1974 Feb;76(2):221-43 PMID: 4822468
  34. Existence of homogeneous categories of mutants exhibiting various conversion patterns in gene 75 of Ascobolus immersus.
    Genetics. 1969 Dec;63(4):795-805 PMID: 5399398
  35. Polarized recombination and fine structure within the me-2 gene of Neurospora crassa.
    Genetics. 1963 Sep;48:1163-83 PMID: 13936784
Article Info
Journal
Molecular & general genetics : MGG
Abbr.
Mol Gen Genet
ISSN
0026-8925
DOI
10.1007/BF00334304
Published
1979-10-02
Pages
129-38
Language
English
Region
Germany
NLM ID
0125036
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00334304
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