Protein Folding: A Perspective from Theory and Experiment.

Angewandte Chemie (International ed. in English) ·Vol. 37 ·No. 7 ·1998-04-20 ·Pages 868-893

Dobson CM, Šali A, Karplus M

Abstract

The mechanism of protein folding (represented schematically below) is one of the most fascinating problems in the field of chemical reactions. This review presents the progess made recently in understanding key elements of this reaction and describes a solution to the often quoted Levinthal Paradox.

Keywords

Kinetics Molecular dynamics Protein folding Proteins Structure elucidation

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Dobson Christopher M

Oxford Centre for Molecular Sciences, New Chemistry Laboratory, University of Oxford, South Parks Road, Oxford OX1 3QT (UK), Fax: (+44) 1-865-275-921.

Šali Andrej

The Rockefeller University, New York, NY (USA).

Karplus Martin

Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138 (USA), Fax: (+1) 617-496-3204 (and) Laboratoire de Chimie Biophysique, Institut Le Bel, Universite Louis Pasteur, F-67000 Strasbourg (France), Fax: (+33) 388-60-83-63.

Article Info

Journal

Angewandte Chemie (International ed. in English)

Abbr.

Angew Chem Int Ed Engl

ISSN

1521-3773

DOI

10.1002/(SICI)1521-3773(19980420)37:7<868::AID-ANIE868>3.0.CO;2-H

Published

1998-04-20

Pages

868-893

Language

English

Region

Germany

NLM ID

0370543

External Links

PubMed source DOI: 10.1002/(SICI)1521-3773(19980420)37:7<868::AID-ANIE868>3.0.CO;2-H View journal details

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