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PMID: 2973063 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Mapping of the gene encoding the beta-amyloid precursor protein and its relationship to the Down syndrome region of chromosome 21.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 85 ·No. 21 ·1988-11-00 ·Pages 8266-70

Patterson D, Gardiner K, Kao FT, Tanzi R, Watkins P, Gusella JF

Abstract

The gene encoding the beta-amyloid precursor protein has been assigned to human chromosome 21, as has a gene responsible for at least some cases of familial Alzheimer disease. Linkage studies strongly suggest that the beta-amyloid precursor protein and the product corresponding to familial Alzheimer disease are from two genes, or at least that several million base pairs of DNA separate the markers. The precise location of the beta-amyloid precursor protein gene on chromosome 21 has not yet been determined. Here we show, by using a somatic-cell/hybrid-cell mapping panel, in situ hybridization, and transverse-alternating-field electrophoresis, that the beta-amyloid precursor protein gene is located on chromosome 21 very near the 21q21/21q22 border and probably within the region of chromosome 21 that, when trisomic, results in Down syndrome.

MeSH Terms
Alzheimer Disease/genetics Amyloid/genetics Amyloid beta-Protein Precursor Chromosome Banding Chromosome Mapping Chromosomes, Human, Pair 21 Down Syndrome/genetics Genetic Linkage Humans Nucleic Acid Hybridization Protein Precursors/genetics
Chemicals
Amyloid Amyloid beta-Protein Precursor Protein Precursors
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Patterson D
Eleanor Roosevelt Institute for Cancer Research, Denver, CO 80206.
Gardiner K
Kao F T
Tanzi R
Watkins P
Gusella J F
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.85.21.8266
Published
1988-11-00
Pages
8266-70
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC282410
Subset
IM
Grants
NIA NIH HHS · AG00029 · United States
NCI NIH HHS · CB02080 · United States
NICHD NIH HHS · HD17749 · United States
External Links
PubMed source DOI: 10.1073/pnas.85.21.8266 PMC Full Text View journal details
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