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PMID: 2982162 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Genetic control of chromosome length in yeast.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 82 ·No. 2 ·1985-01-00 ·Pages 506-10

Walmsley RM, Petes TD

Abstract

The chromosomes of the yeast Saccharomyces cerevisiae terminate with sequences that have the form poly(C1-3-A). In this paper, we show that within an individual yeast strain all chromosomes end with tracts of poly(C1-3-A) of similar lengths; however, different strains can have tracts that vary in length by a factor of two. By a genetic analysis, we demonstrate that yeast cells have a mechanism that allows them to change rapidly the length of their chromosomes by altering the length of the poly(C1-3-A) tract.

MeSH Terms
Base Sequence Chromosomes/analysis DNA Replication DNA Restriction Enzymes/metabolism Electrophoresis, Agar Gel Meiosis Nucleic Acid Conformation Poly A/analysis Poly C/analysis Polyribonucleotides/analysis Repetitive Sequences, Nucleic Acid Saccharomyces cerevisiae/genetics
Chemicals
Polyribonucleotides Poly A poly(A-C) Poly C DNA Restriction Enzymes
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Walmsley R M
Petes T D
References (13)
13 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.82.2.506
Published
1985-01-00
Pages
506-10
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC397068
Subset
IM
Grants
NCI NIH HHS · CA 19265 · United States
NIGMS NIH HHS · GM 24110 · United States
NIA NIH HHS · K 04 AG 00077 · United States
External Links
PubMed source DOI: 10.1073/pnas.82.2.506 PMC Full Text View journal details
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