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PMID: 2983004 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Human papillomavirus type 16 recombinant DNA is maintained as an autonomously replicating episome in monkey kidney cells.

The Journal of general virology ·Vol. 66 ( Pt 3) ·1985-03-00 ·Pages 615-20

Chesters PM, McCance DJ

Abstract

Human papillomavirus type 16 (HPV16) DNA cloned in the expression vector pSV2-neo has been shown to be maintained in transfected monkey kidney cells as an autonomously replicating episome at a level of 2 to 10 copies per cell. Integration of pSV2-neo/HPV16 DNA with the host genome occurred in transfected mouse fibroblasts. Neither type of cell appeared to be phenotypically transformed.

MeSH Terms
Animals Cells, Cultured Cloning, Molecular DNA Replication DNA, Recombinant DNA, Viral/genetics Haplorhini Kidney/microbiology Papillomaviridae/genetics Plasmids Transcription, Genetic Transfection
Chemicals
DNA, Recombinant DNA, Viral
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Chesters P M
McCance D J
Article Info
Journal
The Journal of general virology
Abbr.
J Gen Virol
ISSN
0022-1317
DOI
10.1099/0022-1317-66-3-615
Published
1985-03-00
Pages
615-20
Language
English
Region
England
NLM ID
0077340
Subset
IM
External Links
PubMed source DOI: 10.1099/0022-1317-66-3-615 View journal details
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