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PMID: 2985799 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Induction of angiosarcoma by a c-erbB transducing virus.

Journal of virology ·Vol. 54 ·No. 2 ·1985-05-00 ·Pages 304-10

Tracy SE, Woda BA, Robinson HL

Abstract

Recently, 12 new transductions of c-erbB have been identified in a series of Rous-associated virus type 1-induced erythroleukemias. During the passage of these new transducing viruses it has become apparent that the erythroleukemia in chicken 5005 contained two different c-erbB transducing viruses. One induces erythroblastosis, whereas the second induces angiosarcoma. The angiosarcoma- and erythroblastosis-inducing viruses appear to have had a common ancestor, since tumors induced by each contain a novel, 4.3-kilobase c-erbB-related EcoRI fragment. The angiosarcoma-inducing virus has been named avian angiosarcoma virus and is designated for the chicken in which it originated.

MeSH Terms
Animals Avian Leukosis/etiology Avian Leukosis Virus/genetics,isolation & purification,pathogenicity Base Sequence Chickens Hemangiosarcoma/etiology,pathology Transduction, Genetic
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Tracy S E
Woda B A
Robinson H L
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.54.2.304-310.1985
Published
1985-05-00
Pages
304-10
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC254798
Subset
IM
Grants
PHS HHS · P30 12708 · United States
NCI NIH HHS · R01 CA23086 · United States
NCI NIH HHS · R01 CA27223 · United States
External Links
PubMed source DOI: 10.1128/JVI.54.2.304-310.1985 PMC Full Text View journal details
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