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PMID: 2988943 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Evidence for a repeating domain in type I restriction enzymes.

The EMBO journal ·Vol. 4 ·No. 5 ·1985-05-00 ·Pages 1351-5

Argos P

Abstract

The primary structures of the recognition subunit (hsdS) in type I restriction enzymes from three isolates of Escherichia coli were compared and aligned by use of amino acid physical properties. A repeating domain was found in each of the subunits suggesting a pseudo-dimeric structure. Secondary structure predictions delineated two helical regions in each domain which suggested that the recognition subunits may act in a fashion similar to that proposed for repressor and activator molecules; namely, interaction with double-stranded DNA through helices and in two successive major grooves on the same DNA side. One helical motif could provide the specific recognition site and the other, the restriction site.

MeSH Terms
Amino Acid Sequence Amino Acids/analysis Binding Sites DNA Restriction Enzymes/analysis Escherichia coli/enzymology Receptors, Cyclic AMP/analysis
Chemicals
Amino Acids Receptors, Cyclic AMP DNA Restriction Enzymes
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Argos P
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25 references, click to expand
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1985-05-00
Pages
1351-5
Language
English
Region
England
NLM ID
8208664
PMCID
PMC554348
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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