To describe 2 cases of gastric dilatation-volvulus (GDV) in cats. To describe 2 unique clinical settings in which the disease occurs in cats, and to highlight the differences between GDV in cats and dogs. Two neutered female Persian cats were presented for evaluation of respiratory distress. Initial physical examination revealed tachypnea, dyspnea, and a markedly distended and painful abdomen in both cats. Radiographs revealed a gas-dilated stomach and gastrointestinal (GI) tract in both cats but were only diagnostic for GDV in 1 case. Gastric dilatation-volvulus was confirmed during exploratory laparotomy and gastropexy was performed in each case. Both cats were successfully discharged from the hospital. Gastric dilatation-volvulus in cats is a rare event and appears to occur in 2 clinical settings: in combination with traumatic diaphragmatic hernia (as previously reported) and without a history of trauma or diaphragmatic hernia, as in the 2 cases reported here. Clinicians should consider GDV in the list of differentials for cats with respiratory distress and abdominal distension, even if classic radiographic findings are not present.
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