Monoclonal antibodies specific for p24, the major core protein of human T-cell leukemia virus type III.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 82 ·No. 15 ·1985-08-00 ·Pages 5199-202

di Marzo Veronese F, Sarngadharan MG, Rahman R, Markham PD, Popovic M, Bodner AJ, Gallo RC

Abstract

Four mouse hybridomas secreting monoclonal antibodies specific for p24, the major core antigen of the human T-cell leukemia virus type III (HTLV-III), have been developed, and their specificities have been partially characterized. These antibodies specifically recognized p24 of HTLV-III in extracts of HTLV-III and in HTLV-III-producing cells. No epitopes cross-reactive with HTLV-I and -II were detected with these antibodies. These hybridomas will be extremely valuable reagents in identifying expression of HTLV-III in infected cultures and in cells or tissues from patients with suspected immunodeficiency syndrome.

MeSH Terms

Acquired Immunodeficiency Syndrome/diagnosis Antibodies, Monoclonal/immunology Antibodies, Viral/immunology Antibody Specificity Deltaretrovirus/immunology Humans Molecular Weight Viral Core Proteins Viral Proteins/immunology

Chemicals

Antibodies, Monoclonal Antibodies, Viral Viral Core Proteins Viral Proteins

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

di Marzo Veronese F

Sarngadharan M G

Rahman R

Markham P D

Popovic M

Bodner A J

Gallo R C

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.82.15.5199

Published

1985-08-00

Pages

5199-202

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC390527

Subset

External Links

PubMed source DOI: 10.1073/pnas.82.15.5199 PMC Full Text View journal details

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Monoclonal antibodies specific for p24, the major core protein of human T-cell leukemia virus type III.

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