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PMID: 2994241 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Transformation associated p53 protein is encoded by a gene on human chromosome 17.

Somatic cell and molecular genetics ·Vol. 11 ·No. 5 ·1985-09-00 ·Pages 505-10

Benchimol S, Lamb P, Crawford LV, Sheer D, Shows TB, Bruns GA, Peacock J

Abstract

The human gene for the transformation-associated p53 phosphoprotein (P53) was assigned to the short arm of chromosome 17 using human-rodent somatic cell hybrids and Southern filter hybridization of cell hybrid DNA. The filters were hybridized to radiolabeled DNA from a genomic clone which contained P53 nucleotide sequences. Hybridization of the probe to a 2.5-kb human DNA fragment in HindIII-digested DNA was used to identify the human P53 gene.

MeSH Terms

Animals Cell Line Cell Transformation, Neoplastic Chromosome Mapping Chromosomes, Human, 16-18 Cricetinae Cricetulus DNA/genetics DNA Restriction Enzymes Electrophoresis, Agar Gel Genes Genetic Markers Humans Hybrid Cells Mice Neoplasm Proteins/genetics Nucleic Acid Hybridization Phosphoproteins/genetics Tumor Suppressor Protein p53

Chemicals

Genetic Markers Neoplasm Proteins Phosphoproteins Tumor Suppressor Protein p53 DNA DNA Restriction Enzymes

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Benchimol S

Lamb P

Crawford L V

Sheer D

Shows T B

Bruns G A

Peacock J

Article Info

Journal

Somatic cell and molecular genetics

Abbr.

Somat Cell Mol Genet

ISSN

0740-7750

DOI

10.1007/BF01534845

Published

1985-09-00

Pages

505-10

Language

English

Region

United States

NLM ID

8403568

Subset

Grants

NIGMS NIH HHS · GM20454 · United States

NICHD NIH HHS · HD18658 · United States

External Links

PubMed source DOI: 10.1007/BF01534845

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Transformation associated p53 protein is encoded by a gene on human chromosome 17.

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