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PMID: 2995183 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

HLA-DR3 and -DR4 control T-lymphocyte responses to mumps and Coxsackie B4 virus: studies on patients with type 1 (insulin-dependent) diabetes and healthy subjects.

Diabetologia ·Vol. 28 ·No. 7 ·1985-07-00 ·Pages 420-6

Bruserud O, Jervell J, Thorsby E

Abstract

To study the relationships between the responses to viral antigens and the HLA-DR3 and -DR4 associations in Type 1 (insulin-dependent) diabetes mellitus, the frequency of T-lymphocyte proliferating in response to mumps, Coxsackie B4 and varicella-zoster antigens was determined. A decreased frequency was found in T lymphocytes able to respond to mumps or Coxsackie B4 when presented together with DR3, as compared with the frequency of T lymphocytes able to respond to these viruses together with other DR determinants. This was not found for varicella-zoster or purified protein derivative of tuberculin. In contrast, an increased frequency was found in T lymphocytes responding to mumps or Coxsackie B4 together with DR4, compared with other DR determinants. The results were similar in Type 1 diabetic and healthy individuals. The results suggest that elements on the DR3 and DR4 molecules may control T-lymphocyte responses to mumps and Coxsackie B4 viruses.

MeSH Terms
Adult Antigen-Presenting Cells/immunology Antigens, Viral/immunology Diabetes Mellitus, Type 1/immunology Enterovirus B, Human/immunology Female HLA-DR Antigens Herpesvirus 3, Human/immunology Histocompatibility Antigens Class II/immunology Humans Lymphocyte Activation Male Middle Aged Mumps virus/immunology T-Lymphocytes/immunology Tuberculin/immunology
Chemicals
Antigens, Viral HLA-DR Antigens Histocompatibility Antigens Class II Tuberculin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Bruserud O
Jervell J
Thorsby E
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31 references, click to expand
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Article Info
Journal
Diabetologia
Abbr.
Diabetologia
ISSN
0012-186X
DOI
10.1007/BF00280884
Published
1985-07-00
Pages
420-6
Language
English
Region
Germany
NLM ID
0006777
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00280884 View journal details
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