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PMID: 2995998 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Translocation of c-myc in the hereditary renal cell carcinoma associated with a t(3;8)(p14.2;q24.13) chromosomal translocation.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 82 ·No. 20 ·1985-10-00 ·Pages 6980-4

Drabkin HA, Bradley C, Hart I, Bleskan J, Li FP, Patterson D

Abstract

A translocation between chromosomes 3 and 8, t(3;8)(p14.2;q24.13), has been reported in a family with hereditary renal cell carcinoma. Using somatic cell hybrids, we have isolated, separately, both derivative chromosomes. We find that the c-myc oncogene (8q24.1) has been translocated to the derivative 3 [der(3)]. We have not detected a rearrangement within an approximately equal to 21-kilobase region around the c-myc gene using restriction enzyme digestion and Southern blot hybridization analysis. The translocated c-myc gene should provide a probe to the chromosome 3p14 region, which appears to be important not only in renal cell carcinoma but also in small cell carcinoma of the lung. These hybrids have also been useful for the regional mapping of the Chinese hamster ovary cell Gly-B defect to 8q22.1----q24.13 and support the regional assignment of acylase I to 3p21.

MeSH Terms
Animals Carcinoma, Renal Cell/genetics Cell Line Chromosome Banding Chromosomes, Human, 1-3 Chromosomes, Human, 6-12 and X Cricetinae Cricetulus Female Humans Karyotyping Kidney Neoplasms/genetics Nucleic Acid Hybridization Oncogenes Ovary Receptors, Cell Surface/genetics Receptors, Transferrin Transferrin/metabolism Translocation, Genetic
Chemicals
Receptors, Cell Surface Receptors, Transferrin Transferrin
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Drabkin H A
Bradley C
Hart I
Bleskan J
Li F P
Patterson D
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.82.20.6980
Published
1985-10-00
Pages
6980-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC391293
Subset
IM
Grants
NIA NIH HHS · AG00029 · United States
External Links
PubMed source DOI: 10.1073/pnas.82.20.6980 PMC Full Text View journal details
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