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PMID: 2998805 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Isolation and characterization of Abelson murine leukemia virus-transformed mast cell lines from midgestation embryonic placenta.

European journal of immunology ·Vol. 15 ·No. 11 ·1985-11-00 ·Pages 1136-41

Siegel ML, Horwitz R, Morris TD, Di Venere RM, Siden EJ

Abstract

Abelson murine leukemia virus was used to transform cells of the midgestation embryonic placenta. The frequency of transformed foci in semisolid agarose was highest when cells were isolated at 10 days of gestation and cell lines could be established in liquid culture. The continuous cell lines express characteristics of cultured mast cells, including surface antigens which are shared with lymphocytes and mononuclear phagocytes. These results imply a relationship between the transforming gene product and the mast cell growth factor interleukin 3.

MeSH Terms
Abelson murine leukemia virus/physiology Animals Antigens, Surface/analysis Cell Count Cell Differentiation Cell Line Cell Separation Cell Transformation, Viral Embryo, Mammalian/cytology,immunology,metabolism Female Histamine/analysis Immunoglobulin Heavy Chains/genetics Leukemia Virus, Murine/physiology Leukemia, Experimental/immunology,pathology Mast Cells/analysis,cytology,pathology Mice Mice, Inbred BALB C Mice, Inbred CBA Placenta/cytology,immunology,metabolism Pregnancy Receptors, Fc/analysis
Chemicals
Antigens, Surface Immunoglobulin Heavy Chains Receptors, Fc Histamine
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Siegel M L
Horwitz R
Morris T D
Di Venere R M
Siden E J
Article Info
Journal
European journal of immunology
Abbr.
Eur J Immunol
ISSN
0014-2980
DOI
10.1002/eji.1830151113
Published
1985-11-00
Pages
1136-41
Language
English
Region
Germany
NLM ID
1273201
Subset
IM
Grants
NIAID NIH HHS · 8-T2AIO711OB-07 · United States
External Links
PubMed source DOI: 10.1002/eji.1830151113 View journal details
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