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PMID: 300302 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Ecotaxis: the principle and its application to the study of Hodgkin's disease.

Clinical and experimental immunology ·Vol. 27 ·No. 1 ·1977-01-00 ·Pages 143-51

Sousa MD, Yang M, Lopes-Corrales E, Tan C, Hansen JA, Dupont B, Good RA

Abstract

A study of the function, characterization and distribution of T and B lymphocytes in five children with Hodgkin's disease is presented. The results, indicating that lymphocyte depletion in the peripheral blood does not necessarily reflect an overall lack of circulating lymphocytes, are presented to demonstrate that failure of ecotaxis (normal lymphocyte migration and distribution) can occur in man. The underlying reasons for such failure and their relevance to the pathogenesis of Hodgkin's disease are discussed.

MeSH Terms
Adolescent B-Lymphocytes Child Child, Preschool Dose-Response Relationship, Immunologic Female Hodgkin Disease/immunology Humans Leukocyte Count Lymphocyte Activation Male Mitogens/pharmacology Spleen/immunology Splenectomy T-Lymphocytes
Chemicals
Mitogens
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Sousa M D
Yang M
Lopes-Corrales E
Tan C
Hansen J A
Dupont B
Good R A
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22 references, click to expand
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Article Info
Journal
Clinical and experimental immunology
Abbr.
Clin Exp Immunol
ISSN
0009-9104
Published
1977-01-00
Pages
143-51
Language
English
Region
England
NLM ID
0057202
PMCID
PMC1540896
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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