Identification of three new Ig lambda-like genes in man.
Three new human lambda L chain-like Ig genes are identified by restriction enzyme and nucleotide sequence analysis. Two genes, 14.1 and 16.1, have intact J and C regions, and are potentially functional, with open reading frames. A third gene, 18.1, is a pseudogene. The evolutionary lineage of these genes compared to the known functional locus lambda C1-lambda C6 can be surmised from Southern blot and nucleotide homologies. This study demonstrates that the human lambda gene family is more complex than previously recognized.
19 references, click to expand
-
Chromosomal location of human kappa and lambda immunoglobulin light chain constant region genes.J Exp Med. 1982 May 1;155(5):1480-90 PMID: 6802926
-
Detection of specific sequences among DNA fragments separated by gel electrophoresis.J Mol Biol. 1975 Nov 5;98(3):503-17 PMID: 1195397
-
Rapid similarity searches of nucleic acid and protein data banks.Proc Natl Acad Sci U S A. 1983 Feb;80(3):726-30 PMID: 6572363
-
Variable amplification of immunoglobulin lambda light-chain genes in human populations.Nature. 1983 Jul 14-20;304(5922):172-4 PMID: 6306474
-
A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains.Nature. 1984 Mar 8-14;308(5955):145-9 PMID: 6336315
-
Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins.Nature. 1984 Mar 8-14;308(5955):153-8 PMID: 6546606
-
Structure, organization, and somatic rearrangement of T cell gamma genes.Cell. 1985 Feb;40(2):259-69 PMID: 3917858
-
Diversity and structure of genes of the alpha family of mouse T-cell antigen receptor.Nature. 1985 Aug 29-Sep 4;316(6031):783-7 PMID: 3839904
-
Primary structure of the Mcg lambda chain.Biochemistry. 1974 Sep 24;13(20):4102-14 PMID: 4415202
-
Structure of the human immunoglobulin mu locus: characterization of embryonic and rearranged J and D genes.Cell. 1981 Dec;27(3 Pt 2):583-91 PMID: 6101209
-
Screening lambdagt recombinant clones by hybridization to single plaques in situ.Science. 1977 Apr 8;196(4286):180-2 PMID: 322279
-
The evolution and sequence comparison of two recently diverged mouse chromosomal beta--globin genes.Cell. 1979 Nov;18(3):865-73 PMID: 519759
-
Clustered arrangement of immunoglobulin lambda constant region genes in man.Nature. 1981 Dec 10;294(5841):536-40 PMID: 6273747
-
Evolution of human immunoglobulin kappa J region genes.J Biol Chem. 1982 Feb 10;257(3):1516-22 PMID: 6276389
-
Processed genes: a dispersed human immunoglobulin gene bearing evidence of RNA-type processing.Nature. 1982 Mar 25;296(5855):321-5 PMID: 6801526
-
Unusual organization and diversity of T-cell receptor alpha-chain genes.Nature. 1985 Aug 29-Sep 4;316(6031):828-32 PMID: 2993907
-
Genomic organization of the genes encoding mouse T-cell receptor alpha-chain.Nature. 1985 Aug 29-Sep 4;316(6031):832-6 PMID: 2993908
-
Organization and sequences of the variable, joining and constant region genes of the human T-cell receptor alpha-chain.Nature. 1985 Aug 29-Sep 4;316(6031):837-40 PMID: 2993909
-
The genetics of antibody diversity.Sci Am. 1982 May;246(5):102-15 PMID: 6177035
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