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PMID: 300411 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Suppression of natural killer cell activity with radioactive strontium: effector cells are marrow dependent.

Journal of immunology (Baltimore, Md. : 1950) ·Vol. 118 ·No. 4 ·1977-04-00 ·Pages 1503-6

Haller O, Wigzell H

Abstract

NK cells with lytic capacity for Moloney leukemia virus-induced lymphomas have previously been found to occur spontaneously in spleens from nonimmune adult mice. Here, 89Sr-treatment is shown to suppress NK cell function in adult mice without similarly affecting other cell-mediated immune reactions. Thus, selective 89Sr-sensitivity distinguishes NK cells from other killer cell types. The present results indicate that in vivo a functional bone marrow is needed for generation and maintenance of NK activity.

MeSH Terms

Animals Antigens, Neoplasm B-Lymphocytes/immunology,radiation effects Bone Marrow/immunology,radiation effects Cytotoxicity Tests, Immunologic Female Immunity, Cellular/radiation effects Lymphoma/etiology,immunology Male Mice Mice, Inbred A Mice, Inbred C57BL Mice, Inbred CBA Moloney murine leukemia virus Neoplasms, Experimental/etiology,immunology Spleen/immunology,radiation effects Strontium Radioisotopes/adverse effects T-Lymphocytes/immunology,radiation effects

Chemicals

Antigens, Neoplasm Strontium Radioisotopes

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Haller O

Wigzell H

Article Info

Journal

Journal of immunology (Baltimore, Md. : 1950)

Abbr.

J Immunol

ISSN

0022-1767

Published

1977-04-00

Pages

1503-6

Language

English

Region

United States

NLM ID

2985117R

Subset

External Links

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Suppression of natural killer cell activity with radioactive strontium: effector cells are marrow dependent.

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