Immunological studies of Aging. III. Cytokinetic basis for the impaired response of lymphocytes from aged humans to plant lectins.
The basis for the age-associated defect in the response of lymphocytes to plant lectins has been studied. Using three independent assays we have shown that the number of mitogen-responsive cells is markedly reduced in lymphocyte preparations from old persons. In addition, studies using colchicine bloock and thymidine pulse techniques have revealed a failure of mitogen-responsive cells from old persons to expand into a proliferating pool of lymphocytes as is observed when lymphocytes from young persons are cultured with phytohemagglutinin. Thus, the impaired response of lymphocytes from old persons to mitogens is attributable to a reduced number of mitogen responsive cells and their failure to undergo clonal expansion.
16 references, click to expand
-
The cell biology of human aging.N Engl J Med. 1976 Dec 2;295(23):1302-8 PMID: 980063
-
Lymphocyte responses to phytohaemagglutinin: age-related effects.Immunology. 1976 Oct;31(4):583-7 PMID: 1086285
-
Phytomitogen responses of peripheral blood lymphocytes in young and older subjects.Clin Exp Immunol. 1974 Aug;17(4):657-64 PMID: 4468867
-
Age-related variation in proportion of circulating T cells.Lancet. 1974 Oct 19;2(7886):922-4 PMID: 4138786
-
Lymphocyte phytohemagglutinin responsiveness, immunoglobulins and autoantibodies in aging humans.J Immunol. 1973 Oct;111(4):1101-7 PMID: 4199555
-
Rosette-forming T cells in human peripheral blood at different ages.Cell Immunol. 1974 May;12(2):323-5 PMID: 4549193
-
The sheep-cell rosette: test on human peripheral blood lymyphocytes: an analysis of some analysis of some variable factors in the technique.Br J Haematol. 1974 Oct;28(2):245-51 PMID: 4547974
-
Studies on thymus products. IV. Absence of serum 'thymic activity' in adult NZB and (NZB x NZW) F1 mice.Clin Exp Immunol. 1973 Jun;14(2):247-56 PMID: 4541554
-
Impaired lymphocyte function in aged humans.J Clin Invest. 1974 Jan;53(1):99-104 PMID: 4855547
-
Stimulated lymphocyte cultures: responder recruitment and cell cycle kinetics.J Exp Med. 1974 May 1;139(5):1037-48 PMID: 4825240
-
Studies of human lymphocytes in the newborn and the aged.Am J Med. 1975 May;58(5):620-8 PMID: 1093401
-
Thymopoietin-induced acquisition of responsiveness to T cell mitogens.Cell Immunol. 1975 Dec;20(2):218-28 PMID: 1081912
-
Histocompatibility matching. VI. Miniaturization of the mixed leukocyte culture test: a preliminary report.Transplantation. 1971 Mar;11(3):268-73 PMID: 5558562
-
Cytochemical identification of monocytes and granulocytes.Am J Clin Pathol. 1971 Mar;55(3):283-90 PMID: 5549896
-
An extension of the 51Cr-release assay for the estimation of mouse cytotoxins.Transplantation. 1968 Sep;6(6):761-4 PMID: 5706694
-
Mitogenic effect of phytohaemagglutinin at different ages.Nature. 1967 Jul 8;215(5097):193-4 PMID: 6049119
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: [email protected]
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
