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LiteratureArticle Details
PMID: 3010124
Published · ppublish
English
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review
Cachectin and tumour necrosis factor as two sides of the same biological coin.
Abstract
In response to invasive stimuli macrophages secrete cachectin, a multipotent protein. Prominent among its biological effects is the ability to induce wasting (cachexia) as well as a lethal state of shock. The identity of cachectin and tumour necrosis factor has led to a new view of its therapeutic potential.
MeSH Terms
Amino Acid Sequence
Animals
Antineoplastic Agents
Biological Evolution
Cachexia/physiopathology
Endotoxins/pharmacology
Genes
Glycoproteins/physiology,therapeutic use
Humans
Lipoprotein Lipase/antagonists & inhibitors
Lymphotoxin-alpha/genetics
Proteins/physiology,therapeutic use
Receptors, Cell Surface/physiology
Receptors, Tumor Necrosis Factor
Sequence Homology, Nucleic Acid
Tumor Necrosis Factor-alpha
Chemicals
Antineoplastic Agents
Endotoxins
Glycoproteins
Lymphotoxin-alpha
Proteins
Receptors, Cell Surface
Receptors, Tumor Necrosis Factor
Tumor Necrosis Factor-alpha
Lipoprotein Lipase
Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
Published
1986-00-00
Pages
584-8
Language
English
Region
England
NLM ID
0410462
Subset
IM
Grants
NIAID NIH HHS · AI21359 · United States
NIADDK NIH HHS · AM01314 · United States
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