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PMID: 3012351 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Correlations between T-cell specificity and the structure of the antigen receptor.

Nature ·Vol. 321 ·No. 6067 ·1986-00-00 ·Pages 219-26

Fink PJ, Matis LA, McElligott DL, Bookman M, Hedrick SM

Abstract

The derived amino-acid sequences of the heterodimeric antigen receptors expressed by a series of murine T-cell clones are presented. A comparison of the receptor sequences indicates that several mechanisms for generating receptor diversity can influence T-cell specificity, including junctional diversity, combinatorial joining, and combinatorial chain associations.

MeSH Terms

Amino Acid Sequence Animals Base Sequence Clone Cells/immunology Columbidae Cytochrome c Group/immunology DNA/genetics Genes, MHC Class II Lymphocyte Activation Mutation Receptors, Antigen, T-Cell/genetics,immunology Recombination, Genetic T-Lymphocytes/immunology

Chemicals

Cytochrome c Group Receptors, Antigen, T-Cell DNA

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Fink P J

Matis L A

McElligott D L

Bookman M

Hedrick S M

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/321219a0

Published

1986-00-00

Pages

219-26

Language

English

Region

England

NLM ID

0410462

Subset

Grants

NIAID NIH HHS · AI 00662 · United States

NIAID NIH HHS · AI 21372 · United States

NIGMS NIH HHS · GM 35880 · United States

Databases

GENBANK

X03858, X03859, X03860, X03861, X03862, X03863, X03864, X03865

External Links

PubMed source DOI: 10.1038/321219a0 View journal details

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Correlations between T-cell specificity and the structure of the antigen receptor.

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