Home LiteratureArticle Details

PMID: 3012355 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

A second post-transcriptional trans-activator gene required for HTLV-III replication.

Nature ·Vol. 321 ·No. 6068 ·1986-00-00 ·Pages 412-7

Sodroski J, Goh WC, Rosen C, Dayton A, Terwilliger E, Haseltine W

Abstract

Evidence is provided for the existence of a seventh gene in the genome of human T-lymphotropic virus type III/lymphadenopathy-associated virus. The gene is necessary for replication and acts post-transcriptionally to relieve negative regulation of the messenger RNA for the virion capsid and envelope proteins. These observations suggest mechanisms for regulating both the latent and lytic phases of the virus life cycle.

MeSH Terms

Cell Line DNA Replication DNA Restriction Enzymes Deltaretrovirus/genetics Genes Genes, Viral Humans Lymphocytes Mutation Plasmids Protein Biosynthesis RNA Processing, Post-Transcriptional Transcription, Genetic Transfection Viral Envelope Proteins/genetics Virus Replication

Chemicals

Viral Envelope Proteins DNA Restriction Enzymes

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Sodroski J

Goh W C

Rosen C

Dayton A

Terwilliger E

Haseltine W

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/321412a0

Published

1986-00-00

Pages

412-7

Language

English

Region

England

NLM ID

0410462

Subset

Grants

NCI NIH HHS · CA21082 · United States

NCI NIH HHS · CA40658 · United States

NCI NIH HHS · CA42597 · United States

Databases

GENBANK

K03455, M11840

External Links

PubMed source DOI: 10.1038/321412a0 View journal details

Analysis Services

A second post-transcriptional trans-activator gene required for HTLV-III replication.

Contact

WeChat Official Account