Detection of a second t(14;18) breakpoint cluster region in human follicular lymphomas.
Our results indicate that there are two major breakpoint cluster regions in chromosome 18 DNA for t(14;18) translocations in follicular lymphomas. The absence of a pFL-1 homologous transcript in a cell line containing a pFL-2-detectable translocation suggests that there may be two different pathogenetic consequences of t(14;18) translocations. One possibility is that, despite the distances between them (greater than 20 kb), breakpoints in the two cluster regions in some way affect transcription of the same gene product, which has not yet been identified. Alternatively, two separate transcriptional units may be involved. The availability of DNA probes for each of the two t(14;18) breakpoint cluster regions will allow further studies regarding the biologic significance of these two genetically distinct classes of t(14;18) translocations.
15 references, click to expand
-
Construction of improved M13 vectors using oligodeoxynucleotide-directed mutagenesis.Gene. 1983 Dec;26(1):101-6 PMID: 6323249
-
Immunoglobulin gene rearrangement as a diagnostic criterion of B-cell lymphoma.Proc Natl Acad Sci U S A. 1984 Jan;81(2):593-7 PMID: 6607475
-
Histiocytic lymphoma cell lines: immunologic and cytogenetic studies.Cancer Genet Cytogenet. 1985 Jan 15;14(3-4):205-18 PMID: 3881165
-
Correction of a nucleotide-excision-repair mutation by human chromosome 19 in hamster-human hybrid cells.Somat Cell Mol Genet. 1985 Jan;11(1):87-92 PMID: 3919454
-
Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18.Cell. 1985 Jul;41(3):899-906 PMID: 3924412
-
Involvement of the bcl-2 gene in human follicular lymphoma.Science. 1985 Jun 21;228(4706):1440-3 PMID: 3874430
-
The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining.Science. 1985 Sep 27;229(4720):1390-3 PMID: 3929382
-
Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18.Proc Natl Acad Sci U S A. 1985 Nov;82(21):7439-43 PMID: 2865728
-
Clustering of extensive somatic mutations in the variable region of an immunoglobulin heavy chain gene from a human B cell lymphoma.Cell. 1986 Jan 17;44(1):97-106 PMID: 3079673
-
Structure of the human immunoglobulin mu locus: characterization of embryonic and rearranged J and D genes.Cell. 1981 Dec;27(3 Pt 2):583-91 PMID: 6101209
-
Screening lambdagt recombinant clones by hybridization to single plaques in situ.Science. 1977 Apr 8;196(4286):180-2 PMID: 322279
-
DNA sequencing with chain-terminating inhibitors.Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 PMID: 271968
-
Chromosome abnormalities in poorly differentiated lymphocytic lymphoma.Cancer Res. 1979 Aug;39(8):3119-28 PMID: 582296
-
Distinctive chromosomal abnormalities in histologic subtypes of non-Hodgkin's lymphoma.N Engl J Med. 1982 Nov 11;307(20):1231-6 PMID: 7133054
-
Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation.Science. 1984 Nov 30;226(4678):1097-9 PMID: 6093263
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