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PMID: 3014529 Published · ppublish English Comparative Study Journal Article

Identification of conserved and divergent domains within the envelope gene of the acquired immunodeficiency syndrome retrovirus.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 83 ·No. 14 ·1986-07-00 ·Pages 5038-42

Willey RL, Rutledge RA, Dias S, Folks T, Theodore T, Buckler CE, Martin MA

Abstract

The nucleotide sequences of the envelope genes of an African and a North American acquired immunodeficiency syndrome (AIDS) viral isolate have been determined. When their deduced amino acid sequences were aligned with the envelopes of the lymphoadenopathy and AIDS-associated retrovirus isolates, conserved and divergent regions were readily identified. Hypervariable stretches of 28-74 amino acids, exhibiting 20-30% amino acid identity at each position and characterized by reciprocal insertions and deletions, were confined to the gp120 external envelope protein. The origin and clinical implications of the AIDS viral env gene diversity are discussed.

MeSH Terms
Acquired Immunodeficiency Syndrome/microbiology Amino Acid Sequence Base Sequence Deltaretrovirus/genetics,isolation & purification Democratic Republic of the Congo Humans Lymphatic Diseases/microbiology New York RNA Processing, Post-Transcriptional RNA, Messenger/genetics RNA, Viral/genetics Viral Envelope Proteins/genetics
Chemicals
RNA, Messenger RNA, Viral Viral Envelope Proteins
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Willey R L
Rutledge R A
Dias S
Folks T
Theodore T
Buckler C E
Martin M A
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34 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.83.14.5038
Published
1986-07-00
Pages
5038-42
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC323885
Subset
IM
Databases
GENBANK
K03346, K03347, K03455
External Links
PubMed source DOI: 10.1073/pnas.83.14.5038 PMC Full Text View journal details
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