Stimulation of 2',3'-cyclic nucleotide 3'-phosphodiesterase in human lymphocytes by Robinia pseudoacacia lectin.

2',3'-Cyclic nucleotide 3'-phosphodiesterase (CNP) activity was studied in human peripheral blood lymphocytes. Incubation of human lymphocytes with optimum mitogenic concentrations of Robinia pseudoacacia lectin produced an increase in CNP activity. This increase was not detected before 24 h of incubation. Furthermore, whereas unfractionated lymphocytes exhibited activation of CNP, this was not observed in B and T cell subpopulations.