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PMID: 3018732 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Efficient reversion of simian sarcoma virus-transformation and inhibition of growth factor-induced mitogenesis by suramin.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 83 ·No. 17 ·1986-09-00 ·Pages 6440-4

Betsholtz C, Johnsson A, Heldin CH, Westermark B

Abstract

Simian sarcoma virus, an acutely transforming primate retrovirus with capacity to induce gliomas and sarcomas in experimental animals, has acquired its transforming properties by transducing the cellular gene sequences that encode one of the constituent chains of platelet-derived growth factor. Suramin, a drug used in the treatment of trypanosomiasis and onchocerciasis, has previously been reported to inhibit the interaction of platelet-derived growth factor with its cell surface receptor. We show here that suramin efficiently reverts the simian sarcoma virus-induced transformed phenotype in human and rat fibroblasts and propose that this is due to neutralization of an externalized v-sis product. Moreover, we show that suramin inhibits the action of a broad spectrum of growth factors.

MeSH Terms
Animals Avian Sarcoma Viruses Calcium/pharmacology Cell Cycle/drug effects Cell Transformation, Viral/drug effects Epidermal Growth Factor/antagonists & inhibitors ErbB Receptors Humans Mice Platelet-Derived Growth Factor/metabolism Receptors, Cell Surface/metabolism Receptors, Platelet-Derived Growth Factor Sarcoma Virus, Woolly Monkey Sarcoma Viruses, Murine Suramin/pharmacology
Chemicals
Platelet-Derived Growth Factor Receptors, Cell Surface Suramin Epidermal Growth Factor ErbB Receptors Receptors, Platelet-Derived Growth Factor Calcium
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Betsholtz C
Johnsson A
Heldin C H
Westermark B
References (30)
30 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.83.17.6440
Published
1986-09-00
Pages
6440-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC386519
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.83.17.6440 PMC Full Text View journal details
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