Spleen specific expression of an MMTV related transcript associated with the Mtv-6 locus in BALB/c mice.

We have detected an MMTV related transcript which is expressed in a spleen specific manner in BALB/cHeA mice. Using a recombinant inbred series between BALB/cHeA and STS/A mice (C X S RI series) we have identified RNA associated with the Mtv-3 locus of the STS/A strain. This transcript initiates at the same site in the MMTV LTR as already reported for Mtv-2 and Mtv-8. The novel spleen specific MMTV transcript in the BALB/cHeA strain has a different structure as compared to the transcripts associated with the Mtv-2, Mtv-3, or Mtv-8 loci. We have tentatively identified the Mtv-6 locus as the source of these unique transcripts.